CAR T-cell design dependent remodeling of the brain tumor immune microenvironment identify macrophages as key players that inhibit or promote anti-tumor activity

Understanding interactions between adoptively transferred immune cells and the tumor immune microenvironment (TIME) is critical for developing successful T-cell based immunotherapies. Here we investigated the impact of the TIME and chimeric antigen receptor (CAR) design on anti-glioma activity of B7...

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Detalles Bibliográficos
Autores principales: Haydar, Dalia, Ibañez-Vega, Jorge, Crawford, Jeremy Chase, Chou, Ching-Heng, Guy, Cliff, Meehl, Michaela, Yi, Zhongzhen, Langfitt, Deanna, Vogel, Peter, DeRenzo, Christopher, Gottschalk, Stephen, Roussel, Martine F, Thomas, Paul G., Krenciute, Giedre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275057/
https://www.ncbi.nlm.nih.gov/pubmed/37333156
http://dx.doi.org/10.21203/rs.3.rs-2972427/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275057/
https://www.ncbi.nlm.nih.gov/pubmed/37333156
http://dx.doi.org/10.21203/rs.3.rs-2972427/v1

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