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Management of unspecified anxiety disorder: Expert consensus

AIMS: Treatment guidelines with respect to unspecified anxiety disorder have not been published. The aim of this study was to develop a consensus among field experts on the management of unspecified anxiety disorder. METHODS: Experts were asked to evaluate treatment choices based on eight clinical q...

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Autores principales: Sakurai, Hitoshi, Inada, Ken, Aoki, Yumi, Takeshima, Masahiro, Ie, Kenya, Kise, Morito, Yoshida, Eriko, Tsuboi, Takashi, Yamada, Hisashi, Hori, Hikaru, Inada, Yasushi, Shimizu, Eiji, Mishima, Kazuo, Watanabe, Koichiro, Takaesu, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275278/
https://www.ncbi.nlm.nih.gov/pubmed/36811273
http://dx.doi.org/10.1002/npr2.12323
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author Sakurai, Hitoshi
Inada, Ken
Aoki, Yumi
Takeshima, Masahiro
Ie, Kenya
Kise, Morito
Yoshida, Eriko
Tsuboi, Takashi
Yamada, Hisashi
Hori, Hikaru
Inada, Yasushi
Shimizu, Eiji
Mishima, Kazuo
Watanabe, Koichiro
Takaesu, Yoshikazu
author_facet Sakurai, Hitoshi
Inada, Ken
Aoki, Yumi
Takeshima, Masahiro
Ie, Kenya
Kise, Morito
Yoshida, Eriko
Tsuboi, Takashi
Yamada, Hisashi
Hori, Hikaru
Inada, Yasushi
Shimizu, Eiji
Mishima, Kazuo
Watanabe, Koichiro
Takaesu, Yoshikazu
author_sort Sakurai, Hitoshi
collection PubMed
description AIMS: Treatment guidelines with respect to unspecified anxiety disorder have not been published. The aim of this study was to develop a consensus among field experts on the management of unspecified anxiety disorder. METHODS: Experts were asked to evaluate treatment choices based on eight clinical questions concerning unspecified anxiety disorder using a nine‐point Likert scale (1 = “disagree” to 9 = “agree”). According to the responses from 119 experts, the choices were categorized into first‐, second‐, and third‐line recommendations. RESULTS: Benzodiazepine anxiolytic use was not categorized as a first‐line recommendation for the primary treatment of unspecified anxiety disorder, whereas multiple nonpharmacological treatment strategies, including coping strategies (7.9 ± 1.4), psychoeducation for anxiety (7.9 ± 1.4), lifestyle changes (7.8 ± 1.5), and relaxation techniques (7.4 ± 1.8), were categorized as first‐line recommendations. Various treatment strategies were categorized as first‐line recommendations when a benzodiazepine anxiolytic drug did not improve anxiety symptoms, that is, differential diagnosis (8.2 ± 1.4), psychoeducation for anxiety (8.0 ± 1.5), coping strategies (7.8 ± 1.5), lifestyle changes (7.8 ± 1.5), relaxation techniques (7.2 ± 1.9), and switching to selective serotonin reuptake inhibitors (SSRIs) (7.0 ± 1.8). These strategies were also highly endorsed when tapering the dosage of or discontinuing benzodiazepine anxiolytic drugs. There was no first‐line recommendation regarding excusable reasons for continuing benzodiazepine anxiolytics. CONCLUSIONS: The field experts recommend that benzodiazepine anxiolytics should not be used as a first‐line option for patients with unspecified anxiety disorder. Instead, several nonpharmacological interventions and switching to SSRIs were endorsed for the primary treatment of unspecified anxiety disorder and as alternatives to benzodiazepine anxiolytics.
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spelling pubmed-102752782023-06-17 Management of unspecified anxiety disorder: Expert consensus Sakurai, Hitoshi Inada, Ken Aoki, Yumi Takeshima, Masahiro Ie, Kenya Kise, Morito Yoshida, Eriko Tsuboi, Takashi Yamada, Hisashi Hori, Hikaru Inada, Yasushi Shimizu, Eiji Mishima, Kazuo Watanabe, Koichiro Takaesu, Yoshikazu Neuropsychopharmacol Rep Original Articles AIMS: Treatment guidelines with respect to unspecified anxiety disorder have not been published. The aim of this study was to develop a consensus among field experts on the management of unspecified anxiety disorder. METHODS: Experts were asked to evaluate treatment choices based on eight clinical questions concerning unspecified anxiety disorder using a nine‐point Likert scale (1 = “disagree” to 9 = “agree”). According to the responses from 119 experts, the choices were categorized into first‐, second‐, and third‐line recommendations. RESULTS: Benzodiazepine anxiolytic use was not categorized as a first‐line recommendation for the primary treatment of unspecified anxiety disorder, whereas multiple nonpharmacological treatment strategies, including coping strategies (7.9 ± 1.4), psychoeducation for anxiety (7.9 ± 1.4), lifestyle changes (7.8 ± 1.5), and relaxation techniques (7.4 ± 1.8), were categorized as first‐line recommendations. Various treatment strategies were categorized as first‐line recommendations when a benzodiazepine anxiolytic drug did not improve anxiety symptoms, that is, differential diagnosis (8.2 ± 1.4), psychoeducation for anxiety (8.0 ± 1.5), coping strategies (7.8 ± 1.5), lifestyle changes (7.8 ± 1.5), relaxation techniques (7.2 ± 1.9), and switching to selective serotonin reuptake inhibitors (SSRIs) (7.0 ± 1.8). These strategies were also highly endorsed when tapering the dosage of or discontinuing benzodiazepine anxiolytic drugs. There was no first‐line recommendation regarding excusable reasons for continuing benzodiazepine anxiolytics. CONCLUSIONS: The field experts recommend that benzodiazepine anxiolytics should not be used as a first‐line option for patients with unspecified anxiety disorder. Instead, several nonpharmacological interventions and switching to SSRIs were endorsed for the primary treatment of unspecified anxiety disorder and as alternatives to benzodiazepine anxiolytics. John Wiley and Sons Inc. 2023-02-21 /pmc/articles/PMC10275278/ /pubmed/36811273 http://dx.doi.org/10.1002/npr2.12323 Text en © 2023 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Society of Neuropsychopharmacology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Sakurai, Hitoshi
Inada, Ken
Aoki, Yumi
Takeshima, Masahiro
Ie, Kenya
Kise, Morito
Yoshida, Eriko
Tsuboi, Takashi
Yamada, Hisashi
Hori, Hikaru
Inada, Yasushi
Shimizu, Eiji
Mishima, Kazuo
Watanabe, Koichiro
Takaesu, Yoshikazu
Management of unspecified anxiety disorder: Expert consensus
title Management of unspecified anxiety disorder: Expert consensus
title_full Management of unspecified anxiety disorder: Expert consensus
title_fullStr Management of unspecified anxiety disorder: Expert consensus
title_full_unstemmed Management of unspecified anxiety disorder: Expert consensus
title_short Management of unspecified anxiety disorder: Expert consensus
title_sort management of unspecified anxiety disorder: expert consensus
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275278/
https://www.ncbi.nlm.nih.gov/pubmed/36811273
http://dx.doi.org/10.1002/npr2.12323
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