Deep Brain Stimulation for the Treatment of Hemichorea: Case Series and Literature Review

BACKGROUND: Hemichorea (HC) and its severe form hemiballismus (HB) are rare movement disorders which can be medically refractory to treatments and may need surgical intervention. CASE REPORT: We report 3 patients with HC-HB who had meaningful clinical improvement with unilateral deep brain stimulati...

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Autores principales: Masood, Zihan, Domino, Joseph S., Gragg, Antonia, Burchiel, Kim, Kinsman, Michael, Sharma, Vibhash D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ubiquity Press 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275341/
https://www.ncbi.nlm.nih.gov/pubmed/37332655
http://dx.doi.org/10.5334/tohm.765
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author Masood, Zihan
Domino, Joseph S.
Gragg, Antonia
Burchiel, Kim
Kinsman, Michael
Sharma, Vibhash D.
author_facet Masood, Zihan
Domino, Joseph S.
Gragg, Antonia
Burchiel, Kim
Kinsman, Michael
Sharma, Vibhash D.
author_sort Masood, Zihan
collection PubMed
description BACKGROUND: Hemichorea (HC) and its severe form hemiballismus (HB) are rare movement disorders which can be medically refractory to treatments and may need surgical intervention. CASE REPORT: We report 3 patients with HC-HB who had meaningful clinical improvement with unilateral deep brain stimulation (DBS) of the globus pallidus interna (GPi). We identified 8 prior cases of HC-HB treated with GPi-DBS, and a majority of these patients experienced significant improvement in their symptoms. DISCUSSION: GPi-DBS can be considered in medically refractory HC-HB in carefully selected patients. However, data is limited to small case series and further studies are needed.
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spelling pubmed-102753412023-06-17 Deep Brain Stimulation for the Treatment of Hemichorea: Case Series and Literature Review Masood, Zihan Domino, Joseph S. Gragg, Antonia Burchiel, Kim Kinsman, Michael Sharma, Vibhash D. Tremor Other Hyperkinet Mov (N Y) Case Report BACKGROUND: Hemichorea (HC) and its severe form hemiballismus (HB) are rare movement disorders which can be medically refractory to treatments and may need surgical intervention. CASE REPORT: We report 3 patients with HC-HB who had meaningful clinical improvement with unilateral deep brain stimulation (DBS) of the globus pallidus interna (GPi). We identified 8 prior cases of HC-HB treated with GPi-DBS, and a majority of these patients experienced significant improvement in their symptoms. DISCUSSION: GPi-DBS can be considered in medically refractory HC-HB in carefully selected patients. However, data is limited to small case series and further studies are needed. Ubiquity Press 2023-06-12 /pmc/articles/PMC10275341/ /pubmed/37332655 http://dx.doi.org/10.5334/tohm.765 Text en Copyright: © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Masood, Zihan
Domino, Joseph S.
Gragg, Antonia
Burchiel, Kim
Kinsman, Michael
Sharma, Vibhash D.
Deep Brain Stimulation for the Treatment of Hemichorea: Case Series and Literature Review
title Deep Brain Stimulation for the Treatment of Hemichorea: Case Series and Literature Review
title_full Deep Brain Stimulation for the Treatment of Hemichorea: Case Series and Literature Review
title_fullStr Deep Brain Stimulation for the Treatment of Hemichorea: Case Series and Literature Review
title_full_unstemmed Deep Brain Stimulation for the Treatment of Hemichorea: Case Series and Literature Review
title_short Deep Brain Stimulation for the Treatment of Hemichorea: Case Series and Literature Review
title_sort deep brain stimulation for the treatment of hemichorea: case series and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275341/
https://www.ncbi.nlm.nih.gov/pubmed/37332655
http://dx.doi.org/10.5334/tohm.765
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