Complement protein C1q stimulates hyaluronic acid degradation via gC1qR/HABP1/p32 in malignant pleural mesothelioma

Complement component C1q can act as a pro-tumorigenic factor in the tumor microenvironment (TME). The TME in malignant pleural mesothelioma (MPM) is rich in C1q and hyaluronic acid (HA), whose interaction enhances adhesion, migration and proliferation of malignant cells. HA-bound C1q is also capable...

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Detalles Bibliográficos
Autores principales: Balduit, Andrea, Vidergar, Romana, Zacchi, Paola, Mangogna, Alessandro, Agostinis, Chiara, Grandolfo, Micaela, Bottin, Cristina, Salton, Francesco, Confalonieri, Paola, Rocca, Andrea, Zanconati, Fabrizio, Confalonieri, Marco, Kishore, Uday, Ghebrehiwet, Berhane, Bulla, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275365/
https://www.ncbi.nlm.nih.gov/pubmed/37334363
http://dx.doi.org/10.3389/fimmu.2023.1151194

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