Cargando…

Sevoflurane and desflurane effects on early cognitive function after low‐risk surgery: A randomized clinical trial

BACKGROUND AND OBJECTIVES: Deleterious effects on short‐term and long‐term quality of life have been associated with the development of postoperative cognitive dysfunction (POCD) after general anesthesia. Yet, the progress in the field is still required. Most of the studies investigate POCD after ma...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuzminskaite, Vilma, Kontrimaviciute, Egle, Kauzonas, Evaldas, Slauzgalvyte, Ieva, Bukelyte, Greta, Bruzyte‐Narkiene, Greta, Jatuzis, Dalius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275520/
https://www.ncbi.nlm.nih.gov/pubmed/37086000
http://dx.doi.org/10.1002/brb3.3017
_version_ 1785059888311828480
author Kuzminskaite, Vilma
Kontrimaviciute, Egle
Kauzonas, Evaldas
Slauzgalvyte, Ieva
Bukelyte, Greta
Bruzyte‐Narkiene, Greta
Jatuzis, Dalius
author_facet Kuzminskaite, Vilma
Kontrimaviciute, Egle
Kauzonas, Evaldas
Slauzgalvyte, Ieva
Bukelyte, Greta
Bruzyte‐Narkiene, Greta
Jatuzis, Dalius
author_sort Kuzminskaite, Vilma
collection PubMed
description BACKGROUND AND OBJECTIVES: Deleterious effects on short‐term and long‐term quality of life have been associated with the development of postoperative cognitive dysfunction (POCD) after general anesthesia. Yet, the progress in the field is still required. Most of the studies investigate POCD after major surgery, so scarce evidence exists about the incidence and effect different anesthetics have on POCD development after minor procedures. In this study, we compared early postoperative cognitive function of the sevoflurane and desflurane patients who experienced a low‐risk surgery of thyroid gland. MATERIALS AND METHODS: Eighty‐two patients, 40 years and over, with no previous severe cognitive, neurological, or psychiatric disorders, appointed for thyroid surgery under general anesthesia, were included in the study. In a random manner, the patients were allocated to either sevoflurane or desflurane study arms. Cognitive tests assessing memory, attention, and logical reasoning were performed twice: the day before the surgery and 24 h after the procedure. Primary outcome, magnitude of change in cognitive testing, results from baseline. POCD was diagnosed if postoperative score decreased by at least 20%. RESULTS: Median change from baseline cognitive results did not differ between the sevoflurane and desflurane groups (–2.63%, IQR 19.3 vs. 1.13%, IQR 11.0; p = .222). POCD was detected in one patient (1.22%) of the sevoflurane group. Age, duration of anesthesia, postoperative pain, or patient satisfaction did not correlate with test scores. Intraoperative temperature negatively correlated with total postoperative score (r = –0.35, p = .007). CONCLUSIONS: Both volatile agents proved to be equivalent in terms of the early cognitive functioning after low‐risk thyroid surgery. Intraoperative body temperature may influence postoperative cognitive performance.
format Online
Article
Text
id pubmed-10275520
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-102755202023-06-17 Sevoflurane and desflurane effects on early cognitive function after low‐risk surgery: A randomized clinical trial Kuzminskaite, Vilma Kontrimaviciute, Egle Kauzonas, Evaldas Slauzgalvyte, Ieva Bukelyte, Greta Bruzyte‐Narkiene, Greta Jatuzis, Dalius Brain Behav Original Articles BACKGROUND AND OBJECTIVES: Deleterious effects on short‐term and long‐term quality of life have been associated with the development of postoperative cognitive dysfunction (POCD) after general anesthesia. Yet, the progress in the field is still required. Most of the studies investigate POCD after major surgery, so scarce evidence exists about the incidence and effect different anesthetics have on POCD development after minor procedures. In this study, we compared early postoperative cognitive function of the sevoflurane and desflurane patients who experienced a low‐risk surgery of thyroid gland. MATERIALS AND METHODS: Eighty‐two patients, 40 years and over, with no previous severe cognitive, neurological, or psychiatric disorders, appointed for thyroid surgery under general anesthesia, were included in the study. In a random manner, the patients were allocated to either sevoflurane or desflurane study arms. Cognitive tests assessing memory, attention, and logical reasoning were performed twice: the day before the surgery and 24 h after the procedure. Primary outcome, magnitude of change in cognitive testing, results from baseline. POCD was diagnosed if postoperative score decreased by at least 20%. RESULTS: Median change from baseline cognitive results did not differ between the sevoflurane and desflurane groups (–2.63%, IQR 19.3 vs. 1.13%, IQR 11.0; p = .222). POCD was detected in one patient (1.22%) of the sevoflurane group. Age, duration of anesthesia, postoperative pain, or patient satisfaction did not correlate with test scores. Intraoperative temperature negatively correlated with total postoperative score (r = –0.35, p = .007). CONCLUSIONS: Both volatile agents proved to be equivalent in terms of the early cognitive functioning after low‐risk thyroid surgery. Intraoperative body temperature may influence postoperative cognitive performance. John Wiley and Sons Inc. 2023-04-21 /pmc/articles/PMC10275520/ /pubmed/37086000 http://dx.doi.org/10.1002/brb3.3017 Text en © 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Kuzminskaite, Vilma
Kontrimaviciute, Egle
Kauzonas, Evaldas
Slauzgalvyte, Ieva
Bukelyte, Greta
Bruzyte‐Narkiene, Greta
Jatuzis, Dalius
Sevoflurane and desflurane effects on early cognitive function after low‐risk surgery: A randomized clinical trial
title Sevoflurane and desflurane effects on early cognitive function after low‐risk surgery: A randomized clinical trial
title_full Sevoflurane and desflurane effects on early cognitive function after low‐risk surgery: A randomized clinical trial
title_fullStr Sevoflurane and desflurane effects on early cognitive function after low‐risk surgery: A randomized clinical trial
title_full_unstemmed Sevoflurane and desflurane effects on early cognitive function after low‐risk surgery: A randomized clinical trial
title_short Sevoflurane and desflurane effects on early cognitive function after low‐risk surgery: A randomized clinical trial
title_sort sevoflurane and desflurane effects on early cognitive function after low‐risk surgery: a randomized clinical trial
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275520/
https://www.ncbi.nlm.nih.gov/pubmed/37086000
http://dx.doi.org/10.1002/brb3.3017
work_keys_str_mv AT kuzminskaitevilma sevofluraneanddesfluraneeffectsonearlycognitivefunctionafterlowrisksurgeryarandomizedclinicaltrial
AT kontrimaviciuteegle sevofluraneanddesfluraneeffectsonearlycognitivefunctionafterlowrisksurgeryarandomizedclinicaltrial
AT kauzonasevaldas sevofluraneanddesfluraneeffectsonearlycognitivefunctionafterlowrisksurgeryarandomizedclinicaltrial
AT slauzgalvyteieva sevofluraneanddesfluraneeffectsonearlycognitivefunctionafterlowrisksurgeryarandomizedclinicaltrial
AT bukelytegreta sevofluraneanddesfluraneeffectsonearlycognitivefunctionafterlowrisksurgeryarandomizedclinicaltrial
AT bruzytenarkienegreta sevofluraneanddesfluraneeffectsonearlycognitivefunctionafterlowrisksurgeryarandomizedclinicaltrial
AT jatuzisdalius sevofluraneanddesfluraneeffectsonearlycognitivefunctionafterlowrisksurgeryarandomizedclinicaltrial