Antisense oligonucleotides targeting basal forebrain ATXN2 enhances spatial memory and ameliorates sleep deprivation‐induced fear memory impairment in mice

INTRODUCTION: Regulation of brain‐derived neurotrophic factor (BDNF) in the basal forebrain ameliorates sleep deprivation‐induced fear memory impairments in rodents. Antisense oligonucleotides (ASOs) targeting ATXN2 was a potential therapy for spinocerebellar ataxia, whose pathogenic mechanism assoc...

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Detalles Bibliográficos
Autores principales: Ma, Tao, Feng, Long, Wei, Shi‐Nan, Wang, Ying‐Ying, Li, Guan‐Hua, Lu, Yan, Zhang, Ying‐Xin, Chu, Yang, Wang, Wei, Zhang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275523/
https://www.ncbi.nlm.nih.gov/pubmed/37072935
http://dx.doi.org/10.1002/brb3.3013

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