Cargando…

Association of adverse childhood experiences with adulthood multiple sclerosis: A systematic review of observational studies

INTRODUCTION: Adverse childhood experiences (ACEs) are proposed to increase the risk of developing multiple sclerosis (MS) later in life. This systematic review aimed to explore the correlation between ACEs and MS development, age of onset, quality of life in MS patients and MS relapse rates. METHOD...

Descripción completa

Detalles Bibliográficos
Autores principales: Rehan, Syeda Tayyaba, Khan, Zayeema, Shuja, Syed Hasan, Salman, Afia, Hussain, Hassan ul, Abbasi, Muhammad Saif, Razak, Sufyan, Cheema, Huzaifa Ahmad, Swed, Sarya, Surani, Salim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275535/
https://www.ncbi.nlm.nih.gov/pubmed/37128143
http://dx.doi.org/10.1002/brb3.3024
_version_ 1785059891931512832
author Rehan, Syeda Tayyaba
Khan, Zayeema
Shuja, Syed Hasan
Salman, Afia
Hussain, Hassan ul
Abbasi, Muhammad Saif
Razak, Sufyan
Cheema, Huzaifa Ahmad
Swed, Sarya
Surani, Salim
author_facet Rehan, Syeda Tayyaba
Khan, Zayeema
Shuja, Syed Hasan
Salman, Afia
Hussain, Hassan ul
Abbasi, Muhammad Saif
Razak, Sufyan
Cheema, Huzaifa Ahmad
Swed, Sarya
Surani, Salim
author_sort Rehan, Syeda Tayyaba
collection PubMed
description INTRODUCTION: Adverse childhood experiences (ACEs) are proposed to increase the risk of developing multiple sclerosis (MS) later in life. This systematic review aimed to explore the correlation between ACEs and MS development, age of onset, quality of life in MS patients and MS relapse rates. METHODS: We searched a total of six databases in June 2022 and retrieved the relevant studies. The population included adult (18+) individuals who either had been diagnosed or were at risk for developing MS and also had exposure to ACEs. Our primary outcomes include the risks of MS development, age of MS onset, and MS relapse rate in patients who were exposed to different types of ACEs. RESULTS: A total of 11 studies were included in our review. A study reported that among 300 women diagnosed with MS, 71 (24%) reported a history of childhood abuse; moreover, with further research, it was concluded that ACEs were associated with the development of MS. Abuse that occurred 2–3 times per week was associated with an 18.81‐fold increased risk of having MS when compared to the unexposed sample. The relapse rate of MS was found to be substantially greater in severe cases of ACEs compared to individuals who did not report any ACEs. CONCLUSIONS: Results support a significant association between ACEs and the development of MS; individuals with a positive history of ACEs develop MS symptoms earlier. Moreover, the severity of ACEs is also linked with increased relapse rates of MS.
format Online
Article
Text
id pubmed-10275535
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-102755352023-06-17 Association of adverse childhood experiences with adulthood multiple sclerosis: A systematic review of observational studies Rehan, Syeda Tayyaba Khan, Zayeema Shuja, Syed Hasan Salman, Afia Hussain, Hassan ul Abbasi, Muhammad Saif Razak, Sufyan Cheema, Huzaifa Ahmad Swed, Sarya Surani, Salim Brain Behav Reviews INTRODUCTION: Adverse childhood experiences (ACEs) are proposed to increase the risk of developing multiple sclerosis (MS) later in life. This systematic review aimed to explore the correlation between ACEs and MS development, age of onset, quality of life in MS patients and MS relapse rates. METHODS: We searched a total of six databases in June 2022 and retrieved the relevant studies. The population included adult (18+) individuals who either had been diagnosed or were at risk for developing MS and also had exposure to ACEs. Our primary outcomes include the risks of MS development, age of MS onset, and MS relapse rate in patients who were exposed to different types of ACEs. RESULTS: A total of 11 studies were included in our review. A study reported that among 300 women diagnosed with MS, 71 (24%) reported a history of childhood abuse; moreover, with further research, it was concluded that ACEs were associated with the development of MS. Abuse that occurred 2–3 times per week was associated with an 18.81‐fold increased risk of having MS when compared to the unexposed sample. The relapse rate of MS was found to be substantially greater in severe cases of ACEs compared to individuals who did not report any ACEs. CONCLUSIONS: Results support a significant association between ACEs and the development of MS; individuals with a positive history of ACEs develop MS symptoms earlier. Moreover, the severity of ACEs is also linked with increased relapse rates of MS. John Wiley and Sons Inc. 2023-05-01 /pmc/articles/PMC10275535/ /pubmed/37128143 http://dx.doi.org/10.1002/brb3.3024 Text en © 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Rehan, Syeda Tayyaba
Khan, Zayeema
Shuja, Syed Hasan
Salman, Afia
Hussain, Hassan ul
Abbasi, Muhammad Saif
Razak, Sufyan
Cheema, Huzaifa Ahmad
Swed, Sarya
Surani, Salim
Association of adverse childhood experiences with adulthood multiple sclerosis: A systematic review of observational studies
title Association of adverse childhood experiences with adulthood multiple sclerosis: A systematic review of observational studies
title_full Association of adverse childhood experiences with adulthood multiple sclerosis: A systematic review of observational studies
title_fullStr Association of adverse childhood experiences with adulthood multiple sclerosis: A systematic review of observational studies
title_full_unstemmed Association of adverse childhood experiences with adulthood multiple sclerosis: A systematic review of observational studies
title_short Association of adverse childhood experiences with adulthood multiple sclerosis: A systematic review of observational studies
title_sort association of adverse childhood experiences with adulthood multiple sclerosis: a systematic review of observational studies
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275535/
https://www.ncbi.nlm.nih.gov/pubmed/37128143
http://dx.doi.org/10.1002/brb3.3024
work_keys_str_mv AT rehansyedatayyaba associationofadversechildhoodexperienceswithadulthoodmultiplesclerosisasystematicreviewofobservationalstudies
AT khanzayeema associationofadversechildhoodexperienceswithadulthoodmultiplesclerosisasystematicreviewofobservationalstudies
AT shujasyedhasan associationofadversechildhoodexperienceswithadulthoodmultiplesclerosisasystematicreviewofobservationalstudies
AT salmanafia associationofadversechildhoodexperienceswithadulthoodmultiplesclerosisasystematicreviewofobservationalstudies
AT hussainhassanul associationofadversechildhoodexperienceswithadulthoodmultiplesclerosisasystematicreviewofobservationalstudies
AT abbasimuhammadsaif associationofadversechildhoodexperienceswithadulthoodmultiplesclerosisasystematicreviewofobservationalstudies
AT razaksufyan associationofadversechildhoodexperienceswithadulthoodmultiplesclerosisasystematicreviewofobservationalstudies
AT cheemahuzaifaahmad associationofadversechildhoodexperienceswithadulthoodmultiplesclerosisasystematicreviewofobservationalstudies
AT swedsarya associationofadversechildhoodexperienceswithadulthoodmultiplesclerosisasystematicreviewofobservationalstudies
AT suranisalim associationofadversechildhoodexperienceswithadulthoodmultiplesclerosisasystematicreviewofobservationalstudies