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In crystallo observation of active site dynamics and transient metal ion binding within DNA polymerases

DNA polymerases are the enzymatic catalysts that synthesize DNA during DNA replication and repair. Kinetic studies and x-ray crystallography have uncovered the overall kinetic pathway and led to a two-metal-ion dependent catalytic mechanism. Diffusion-based time-resolved crystallography has permitte...

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Detalles Bibliográficos
Autores principales:	Chang, Caleb, Zhou, Grace, Gao, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Crystallographic Association 2023
Materias:	ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275647/ https://www.ncbi.nlm.nih.gov/pubmed/37333512 http://dx.doi.org/10.1063/4.0000187

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