HLH-like toxicities predict poor survival after the use of tisagenlecleucel in children and young adults with B-ALL

Chimeric antigen receptor–associated hemophagocytic lymphohistiocytosis (HLH)–like toxicities (LTs) involving hyperferritinemia, multiorgan dysfunction, coagulopathy, and/or hemophagocytosis are described as occurring in a subset of patients with cytokine release syndrome (CRS). Case series report p...

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Autores principales: McNerney, Kevin O., Si Lim, Stephanie J., Ishikawa, Kyle, Dreyzin, Alexandra, Vatsayan, Anant, Chen, John J., Baggott, Christina, Prabhu, Snehit, Pacenta, Holly L., Philips, Christine, Rossoff, Jenna, Stefanski, Heather E., Talano, Julie-An, Moskop, Amy, Verneris, Michael, Myers, Doug, Karras, Nicole A., Brown, Patrick, Bonifant, Challice L., Qayed, Muna, Hermiston, Michelle, Satwani, Prakash, Krupski, Christa, Keating, Amy K., Baumeister, Susanne H. C., Fabrizio, Vanessa A., Chinnabhandar, Vasant, Egeler, Emily, Mavroukakis, Sharon, Curran, Kevin J., Mackall, Crystal L., Laetsch, Theodore W., Schultz, Liora M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Immunobiology and Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275701/
https://www.ncbi.nlm.nih.gov/pubmed/36857419
http://dx.doi.org/10.1182/bloodadvances.2022008893

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