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m6A methylation regulates hypoxia-induced pancreatic cancer glycolytic metabolism through ALKBH5-HDAC4-HIF1α positive feedback loop

Pancreatic cancer (PC) is the most hypoxic cancer type among solid tumors. The dynamic changes of RNA N6-methyl-adenosine (m6A) contribute to tumor cells adaption to hypoxic microenvironmental. However, the regulatory mechanisms of hypoxia response in PC remains elusive. Here, we reported that the m...

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Detalles Bibliográficos
Autores principales:	Liu, Xiaoyan, Feng, Maoxiao, Hao, Xiaodong, Gao, Zihan, Wu, Zhaoxin, Wang, Yuli, Du, Lutao, Wang, Chuanxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275754/ https://www.ncbi.nlm.nih.gov/pubmed/37149664 http://dx.doi.org/10.1038/s41388-023-02704-8

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