The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics

More than 60 years ago, disulfiram (DSF) was employed for the management of alcohol addiction. This promising cancer therapeutic agent inhibits proliferation, migration, and invasion of malignant tumor cells. Furthermore, divalent copper ions can enhance the antitumor effects of DSF. Molecular struc...

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Autores principales: Zhang, Sijia, Zong, Yan, Chen, Leichong, Li, Qianwen, Li, Zhenyu, Meng, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275851/
https://www.ncbi.nlm.nih.gov/pubmed/37326784
http://dx.doi.org/10.1007/s12672-023-00729-9
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author Zhang, Sijia
Zong, Yan
Chen, Leichong
Li, Qianwen
Li, Zhenyu
Meng, Rui
author_facet Zhang, Sijia
Zong, Yan
Chen, Leichong
Li, Qianwen
Li, Zhenyu
Meng, Rui
author_sort Zhang, Sijia
collection PubMed
description More than 60 years ago, disulfiram (DSF) was employed for the management of alcohol addiction. This promising cancer therapeutic agent inhibits proliferation, migration, and invasion of malignant tumor cells. Furthermore, divalent copper ions can enhance the antitumor effects of DSF. Molecular structure, pharmacokinetics, signaling pathways, mechanisms of action and current clinical results of DSF are summarized here. Additionally, our attention is directed towards the immunomodulatory properties of DSF and we explore novel administration methods that may address the limitations associated with antitumor treatments based on DSF. Despite the promising potential of these various delivery methods for utilizing DSF as an effective anticancer agent, further investigation is essential in order to extensively evaluate the safety and efficacy of these delivery systems.
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spelling pubmed-102758512023-06-18 The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics Zhang, Sijia Zong, Yan Chen, Leichong Li, Qianwen Li, Zhenyu Meng, Rui Discov Oncol Review More than 60 years ago, disulfiram (DSF) was employed for the management of alcohol addiction. This promising cancer therapeutic agent inhibits proliferation, migration, and invasion of malignant tumor cells. Furthermore, divalent copper ions can enhance the antitumor effects of DSF. Molecular structure, pharmacokinetics, signaling pathways, mechanisms of action and current clinical results of DSF are summarized here. Additionally, our attention is directed towards the immunomodulatory properties of DSF and we explore novel administration methods that may address the limitations associated with antitumor treatments based on DSF. Despite the promising potential of these various delivery methods for utilizing DSF as an effective anticancer agent, further investigation is essential in order to extensively evaluate the safety and efficacy of these delivery systems. Springer US 2023-06-16 /pmc/articles/PMC10275851/ /pubmed/37326784 http://dx.doi.org/10.1007/s12672-023-00729-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Zhang, Sijia
Zong, Yan
Chen, Leichong
Li, Qianwen
Li, Zhenyu
Meng, Rui
The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
title The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
title_full The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
title_fullStr The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
title_full_unstemmed The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
title_short The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
title_sort immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275851/
https://www.ncbi.nlm.nih.gov/pubmed/37326784
http://dx.doi.org/10.1007/s12672-023-00729-9
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