Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2

COVID-19 has stimulated the rapid development of new antibody and small molecule therapeutics to inhibit SARS-CoV-2 infection. Here we describe a third antiviral modality that combines the drug-like advantages of both. Bicycles are entropically constrained peptides stabilized by a central chemical s...

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Detalles Bibliográficos
Autores principales: Gaynor, Katherine U., Vaysburd, Marina, Harman, Maximilian A. J., Albecka, Anna, Jeffrey, Phillip, Beswick, Paul, Papa, Guido, Chen, Liuhong, Mallery, Donna, McGuinness, Brian, Van Rietschoten, Katerine, Stanway, Steven, Brear, Paul, Lulla, Aleksei, Ciazynska, Katarzyna, Chang, Veronica T., Sharp, Jo, Neary, Megan, Box, Helen, Herriott, Jo, Kijak, Edyta, Tatham, Lee, Bentley, Eleanor G., Sharma, Parul, Kirby, Adam, Han, Ximeng, Stewart, James P., Owen, Andrew, Briggs, John A. G., Hyvönen, Marko, Skynner, Michael J., James, Leo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275983/
https://www.ncbi.nlm.nih.gov/pubmed/37328472
http://dx.doi.org/10.1038/s41467-023-39158-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275983/
https://www.ncbi.nlm.nih.gov/pubmed/37328472
http://dx.doi.org/10.1038/s41467-023-39158-1

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