Cargando…
An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia
Monocyte-derived macrophages help maintain tissue homeostasis and defend the organism against pathogens. In tumors, recent studies have uncovered complex macrophage populations, including tumor-associated macrophages, which support tumorigenesis through cancer hallmarks such as immunosuppression, an...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275988/ https://www.ncbi.nlm.nih.gov/pubmed/37332613 http://dx.doi.org/10.1016/j.isci.2023.106897 |
_version_ | 1785059981616218112 |
---|---|
author | Verstraete, Nina Marku, Malvina Domagala, Marcin Arduin, Hélène Bordenave, Julie Fournié, Jean-Jacques Ysebaert, Loïc Poupot, Mary Pancaldi, Vera |
author_facet | Verstraete, Nina Marku, Malvina Domagala, Marcin Arduin, Hélène Bordenave, Julie Fournié, Jean-Jacques Ysebaert, Loïc Poupot, Mary Pancaldi, Vera |
author_sort | Verstraete, Nina |
collection | PubMed |
description | Monocyte-derived macrophages help maintain tissue homeostasis and defend the organism against pathogens. In tumors, recent studies have uncovered complex macrophage populations, including tumor-associated macrophages, which support tumorigenesis through cancer hallmarks such as immunosuppression, angiogenesis, or matrix remodeling. In the case of chronic lymphocytic leukemia, these macrophages are known as nurse-like cells (NLCs) and they protect leukemic cells from spontaneous apoptosis, contributing to their chemoresistance. We propose an agent-based model of monocyte differentiation into NLCs upon contact with leukemic B cells in vitro. We performed patient-specific model optimization using cultures of peripheral blood mononuclear cells from patients. Using our model, we were able to reproduce the temporal survival dynamics of cancer cells in a patient-specific manner and to identify patient groups related to distinct macrophage phenotypes. Our results show a potentially important role of phagocytosis in the polarization process of NLCs and in promoting cancer cells’ enhanced survival. |
format | Online Article Text |
id | pubmed-10275988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-102759882023-06-18 An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia Verstraete, Nina Marku, Malvina Domagala, Marcin Arduin, Hélène Bordenave, Julie Fournié, Jean-Jacques Ysebaert, Loïc Poupot, Mary Pancaldi, Vera iScience Article Monocyte-derived macrophages help maintain tissue homeostasis and defend the organism against pathogens. In tumors, recent studies have uncovered complex macrophage populations, including tumor-associated macrophages, which support tumorigenesis through cancer hallmarks such as immunosuppression, angiogenesis, or matrix remodeling. In the case of chronic lymphocytic leukemia, these macrophages are known as nurse-like cells (NLCs) and they protect leukemic cells from spontaneous apoptosis, contributing to their chemoresistance. We propose an agent-based model of monocyte differentiation into NLCs upon contact with leukemic B cells in vitro. We performed patient-specific model optimization using cultures of peripheral blood mononuclear cells from patients. Using our model, we were able to reproduce the temporal survival dynamics of cancer cells in a patient-specific manner and to identify patient groups related to distinct macrophage phenotypes. Our results show a potentially important role of phagocytosis in the polarization process of NLCs and in promoting cancer cells’ enhanced survival. Elsevier 2023-05-19 /pmc/articles/PMC10275988/ /pubmed/37332613 http://dx.doi.org/10.1016/j.isci.2023.106897 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Verstraete, Nina Marku, Malvina Domagala, Marcin Arduin, Hélène Bordenave, Julie Fournié, Jean-Jacques Ysebaert, Loïc Poupot, Mary Pancaldi, Vera An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia |
title | An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia |
title_full | An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia |
title_fullStr | An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia |
title_full_unstemmed | An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia |
title_short | An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia |
title_sort | agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275988/ https://www.ncbi.nlm.nih.gov/pubmed/37332613 http://dx.doi.org/10.1016/j.isci.2023.106897 |
work_keys_str_mv | AT verstraetenina anagentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT markumalvina anagentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT domagalamarcin anagentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT arduinhelene anagentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT bordenavejulie anagentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT fourniejeanjacques anagentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT ysebaertloic anagentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT poupotmary anagentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT pancaldivera anagentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT verstraetenina agentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT markumalvina agentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT domagalamarcin agentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT arduinhelene agentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT bordenavejulie agentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT fourniejeanjacques agentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT ysebaertloic agentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT poupotmary agentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia AT pancaldivera agentbasedmodelofmonocytedifferentiationintotumourassociatedmacrophagesinchroniclymphocyticleukemia |