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An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia

Monocyte-derived macrophages help maintain tissue homeostasis and defend the organism against pathogens. In tumors, recent studies have uncovered complex macrophage populations, including tumor-associated macrophages, which support tumorigenesis through cancer hallmarks such as immunosuppression, an...

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Autores principales: Verstraete, Nina, Marku, Malvina, Domagala, Marcin, Arduin, Hélène, Bordenave, Julie, Fournié, Jean-Jacques, Ysebaert, Loïc, Poupot, Mary, Pancaldi, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275988/
https://www.ncbi.nlm.nih.gov/pubmed/37332613
http://dx.doi.org/10.1016/j.isci.2023.106897
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author Verstraete, Nina
Marku, Malvina
Domagala, Marcin
Arduin, Hélène
Bordenave, Julie
Fournié, Jean-Jacques
Ysebaert, Loïc
Poupot, Mary
Pancaldi, Vera
author_facet Verstraete, Nina
Marku, Malvina
Domagala, Marcin
Arduin, Hélène
Bordenave, Julie
Fournié, Jean-Jacques
Ysebaert, Loïc
Poupot, Mary
Pancaldi, Vera
author_sort Verstraete, Nina
collection PubMed
description Monocyte-derived macrophages help maintain tissue homeostasis and defend the organism against pathogens. In tumors, recent studies have uncovered complex macrophage populations, including tumor-associated macrophages, which support tumorigenesis through cancer hallmarks such as immunosuppression, angiogenesis, or matrix remodeling. In the case of chronic lymphocytic leukemia, these macrophages are known as nurse-like cells (NLCs) and they protect leukemic cells from spontaneous apoptosis, contributing to their chemoresistance. We propose an agent-based model of monocyte differentiation into NLCs upon contact with leukemic B cells in vitro. We performed patient-specific model optimization using cultures of peripheral blood mononuclear cells from patients. Using our model, we were able to reproduce the temporal survival dynamics of cancer cells in a patient-specific manner and to identify patient groups related to distinct macrophage phenotypes. Our results show a potentially important role of phagocytosis in the polarization process of NLCs and in promoting cancer cells’ enhanced survival.
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spelling pubmed-102759882023-06-18 An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia Verstraete, Nina Marku, Malvina Domagala, Marcin Arduin, Hélène Bordenave, Julie Fournié, Jean-Jacques Ysebaert, Loïc Poupot, Mary Pancaldi, Vera iScience Article Monocyte-derived macrophages help maintain tissue homeostasis and defend the organism against pathogens. In tumors, recent studies have uncovered complex macrophage populations, including tumor-associated macrophages, which support tumorigenesis through cancer hallmarks such as immunosuppression, angiogenesis, or matrix remodeling. In the case of chronic lymphocytic leukemia, these macrophages are known as nurse-like cells (NLCs) and they protect leukemic cells from spontaneous apoptosis, contributing to their chemoresistance. We propose an agent-based model of monocyte differentiation into NLCs upon contact with leukemic B cells in vitro. We performed patient-specific model optimization using cultures of peripheral blood mononuclear cells from patients. Using our model, we were able to reproduce the temporal survival dynamics of cancer cells in a patient-specific manner and to identify patient groups related to distinct macrophage phenotypes. Our results show a potentially important role of phagocytosis in the polarization process of NLCs and in promoting cancer cells’ enhanced survival. Elsevier 2023-05-19 /pmc/articles/PMC10275988/ /pubmed/37332613 http://dx.doi.org/10.1016/j.isci.2023.106897 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Verstraete, Nina
Marku, Malvina
Domagala, Marcin
Arduin, Hélène
Bordenave, Julie
Fournié, Jean-Jacques
Ysebaert, Loïc
Poupot, Mary
Pancaldi, Vera
An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia
title An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia
title_full An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia
title_fullStr An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia
title_full_unstemmed An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia
title_short An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia
title_sort agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275988/
https://www.ncbi.nlm.nih.gov/pubmed/37332613
http://dx.doi.org/10.1016/j.isci.2023.106897
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