Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges

Arginine-rich dipeptide repeat proteins (R-DPRs), poly(PR) and poly(GR), translated from the hexanucleotide repeat expansion in the amyotrophic lateral sclerosis (ALS)-causative C9ORF72 gene, contribute significantly to pathogenesis of ALS. Although both R-DPRs share many similarities, there are cri...

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Detalles Bibliográficos
Autores principales: Miyagi, Tamami, Ueda, Koji, Sugimoto, Masahiro, Yagi, Takuya, Ito, Daisuke, Yamazaki, Rio, Narumi, Satoshi, Hayamizu, Yuhei, Uji-i, Hiroshi, Kuroda, Masahiko, Kanekura, Kohsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275993/
https://www.ncbi.nlm.nih.gov/pubmed/37332605
http://dx.doi.org/10.1016/j.isci.2023.106957

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