Cargando…

Dyrk2 gene transfer suppresses hepatocarcinogenesis by promoting the degradation of Myc and Hras

BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and has a poor prognosis. However, the molecular mechanisms underlying hepatocarcinogenesis and progression remain unknown. In vitro gain- and loss-of-function analyses in cell lines and xenografts rev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kamioka, Hiroshi, Yogosawa, Satomi, Oikawa, Tsunekazu, Aizawa, Daisuke, Ueda, Kaoru, Saeki, Chisato, Haruki, Koichiro, Shimoda, Masayuki, Ikegami, Toru, Nishikawa, Yuji, Saruta, Masayuki, Yoshida, Kiyotsugu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275997/ https://www.ncbi.nlm.nih.gov/pubmed/37333975 http://dx.doi.org/10.1016/j.jhepr.2023.100759

Ejemplares similares

Serum Insulin-Like Growth Factor 1 Levels, Facture Risk Assessment Tool Scores and Bone Disorders in Patients with Primary Biliary Cholangitis
por: Saeki, Chisato, et al.
Publicado: (2022)

Low geriatric nutritional risk index predicts poor prognosis in patients with cirrhosis: a retrospective study
por: Kamioka, Hiroshi, et al.
Publicado: (2023)

Centrilobular zonal necrosis is a unique subtype of autoimmune hepatitis: A cohort study
por: Ueda, Kaoru, et al.
Publicado: (2022)

Safety and efficacy of pentazocine–midazolam combination for pain and anxiety relief in radiofrequency ablation therapy for hepatocellular carcinoma
por: Nakano, Masanori, et al.
Publicado: (2022)

Prognostic significance of sarcopenia and severe vitamin D deficiency in patients with cirrhosis
por: Saeki, Chisato, et al.
Publicado: (2023)

Insulin-like growth factor 1 predicts decompensation and long-term prognosis in patients with compensated cirrhosis
por: Saeki, Chisato, et al.
Publicado: (2023)

Osteosarcopenia predicts poor survival in patients with cirrhosis: a retrospective study
por: Saeki, Chisato, et al.
Publicado: (2023)

The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis
por: Yoshida, Saishu, et al.
Publicado: (2020)

The Geriatric Nutritional Risk Index predicts sarcopenia in patients with cirrhosis
por: Saeki, Chisato, et al.
Publicado: (2023)

Recent Insights Into the Multiple Pathways Driving Non-alcoholic Steatohepatitis-Derived Hepatocellular Carcinoma
por: Takakura, Kazuki, et al.
Publicado: (2019)

Low Serum Branched-chain Amino Acid and Insulin-Like Growth Factor-1 Levels Are Associated with Sarcopenia and Slow Gait Speed in Patients with Liver Cirrhosis
por: Saeki, Chisato, et al.
Publicado: (2020)

Effects of denosumab treatment in chronic liver disease patients with osteoporosis
por: Saeki, Chisato, et al.
Publicado: (2020)

Low Serum 25-Hydroxyvitamin D Levels Are Related to Frailty and Sarcopenia in Patients with Chronic Liver Disease
por: Saeki, Chisato, et al.
Publicado: (2020)

Clinical characteristics of sarcopenia in patients with alcoholic liver cirrhosis
por: Saeki, Chisato, et al.
Publicado: (2021)

Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient
por: Yogosawa, Satomi, et al.
Publicado: (2021)

Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma
por: Takakura, Kazuki, et al.
Publicado: (2018)

Relationship between Osteosarcopenia and Frailty in Patients with Chronic Liver Disease
por: Saeki, Chisato, et al.
Publicado: (2020)

Plasma pentosidine levels are associated with prevalent fractures in patients with chronic liver disease
por: Saeki, Chisato, et al.
Publicado: (2021)

Clinical Usefulness of FRAX Score for Predicting Sarcopenia in Patients with Chronic Liver Disease
por: Saeki, Chisato, et al.
Publicado: (2021)

Tumor suppressive role for kinases phosphorylating p53 in DNA damage‐induced apoptosis
por: Yogosawa, Satomi, et al.
Publicado: (2018)

Relationship between osteoporosis, sarcopenia, vertebral fracture, and osteosarcopenia in patients with primary biliary cholangitis
por: Saeki, Chisato, et al.
Publicado: (2020)

Histological and biochemical evaluation of transforming growth factor-β activation and its clinical significance in patients with chronic liver disease
por: Yokoyama, Hiroshi, et al.
Publicado: (2019)

Functional Roles of DYRK2 as a Tumor Regulator
por: Mochimaru, Yuta, et al.
Publicado: (2023)

Identification of circulating microRNAs as potential biomarkers for hepatic necroinflammation in patients with autoimmune hepatitis
por: Saeki, Chisato, et al.
Publicado: (2022)

New insights into the roles for DYRK family in mammalian development and congenital diseases
por: Yoshida, Saishu, et al.
Publicado: (2022)

Role of the Mitochondrial Citrate-malate Shuttle in Hras12V-Induced Hepatocarcinogenesis: A Metabolomics-Based Analysis
por: Lei, Chuanyi, et al.
Publicado: (2020)

Comparative assessment of sarcopenia using the JSH, AWGS, and EWGSOP2 criteria and the relationship between sarcopenia, osteoporosis, and osteosarcopenia in patients with liver cirrhosis
por: Saeki, Chisato, et al.
Publicado: (2019)

HRas and Myc synergistically induce cell cycle progression and apoptosis of murine cardiomyocytes
por: Boikova, Aleksandra, et al.
Publicado: (2022)

Extracellular PKCδ signals to epidermal growth factor receptor for tumor proliferation in liver cancer cells
por: Yamada, Kohji, et al.
Publicado: (2022)

Critical role of Myc activation in mouse hepatocarcinogenesis induced by the activation of AKT and RAS pathways
por: Xin, B, et al.
Publicado: (2017)

Downregulation of CD24 suppresses bone metastasis of lung cancer
por: Okabe, Hinako, et al.
Publicado: (2017)

Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B(+) vesicle pathway in liver cancer
por: Yamada, Kohji, et al.
Publicado: (2022)

Pivotal Role of Fatty Acid Synthase in c-MYC Driven Hepatocarcinogenesis
por: Jia, Jiaoyuan, et al.
Publicado: (2020)

Dual‐specificity tyrosine‐regulated kinase 2 is a suppressor and potential prognostic marker for liver metastasis of colorectal cancer
por: Ito, Daisuke, et al.
Publicado: (2017)

Clinical implications of drug-screening assay for recurrent metastatic hormone receptor-positive, human epidermal receptor 2-negative breast cancer using conditionally reprogrammed cells
por: Mimoto, Rei, et al.
Publicado: (2019)

Sleeping Beauty transposon system harboring HRAS, c-Myc and shp53 induces sarcomatoid carcinomas in mouse skin
por: JUNG, SUNYOUNG, et al.
Publicado: (2013)

Omics-Based Identification of Shared and Gender Disparity Routes in Hras12V-Induced Hepatocarcinogenesis: An Important Role for Dlk1-Dio3 Genomic Imprinting Region
por: Zhang, Jing, et al.
Publicado: (2021)

Tumor Suppressor DYRK1A Effects on Proliferation and Chemoresistance of AML Cells by Downregulating c-Myc
por: Liu, Qiang, et al.
Publicado: (2014)

Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis
por: Cigliano, Antonio, et al.
Publicado: (2017)

Clinical usefulness of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis
por: Torisu, Yuichi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_6pbidftrjpb4l30oa1vuoumg06