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Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics
Loss of a kidney results in compensatory growth of the remaining kidney, a phenomenon of considerable clinical importance. However, the mechanisms involved are largely unknown. Here, we use a multi-omic approach in a unilateral nephrectomy model in male mice to identify signaling processes associate...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276015/ https://www.ncbi.nlm.nih.gov/pubmed/37328470 http://dx.doi.org/10.1038/s41467-023-38958-9 |
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author | Kikuchi, Hiroaki Chou, Chung-Lin Yang, Chin-Rang Chen, Lihe Jung, Hyun Jun Park, Euijung Limbutara, Kavee Carter, Benjamin Yang, Zhi-Hong Kun, Julia F. Remaley, Alan T. Knepper, Mark A. |
author_facet | Kikuchi, Hiroaki Chou, Chung-Lin Yang, Chin-Rang Chen, Lihe Jung, Hyun Jun Park, Euijung Limbutara, Kavee Carter, Benjamin Yang, Zhi-Hong Kun, Julia F. Remaley, Alan T. Knepper, Mark A. |
author_sort | Kikuchi, Hiroaki |
collection | PubMed |
description | Loss of a kidney results in compensatory growth of the remaining kidney, a phenomenon of considerable clinical importance. However, the mechanisms involved are largely unknown. Here, we use a multi-omic approach in a unilateral nephrectomy model in male mice to identify signaling processes associated with renal compensatory hypertrophy, demonstrating that the lipid-activated transcription factor peroxisome proliferator-activated receptor alpha (PPARα) is an important determinant of proximal tubule cell size and is a likely mediator of compensatory proximal tubule hypertrophy. |
format | Online Article Text |
id | pubmed-10276015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102760152023-06-18 Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics Kikuchi, Hiroaki Chou, Chung-Lin Yang, Chin-Rang Chen, Lihe Jung, Hyun Jun Park, Euijung Limbutara, Kavee Carter, Benjamin Yang, Zhi-Hong Kun, Julia F. Remaley, Alan T. Knepper, Mark A. Nat Commun Article Loss of a kidney results in compensatory growth of the remaining kidney, a phenomenon of considerable clinical importance. However, the mechanisms involved are largely unknown. Here, we use a multi-omic approach in a unilateral nephrectomy model in male mice to identify signaling processes associated with renal compensatory hypertrophy, demonstrating that the lipid-activated transcription factor peroxisome proliferator-activated receptor alpha (PPARα) is an important determinant of proximal tubule cell size and is a likely mediator of compensatory proximal tubule hypertrophy. Nature Publishing Group UK 2023-06-16 /pmc/articles/PMC10276015/ /pubmed/37328470 http://dx.doi.org/10.1038/s41467-023-38958-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kikuchi, Hiroaki Chou, Chung-Lin Yang, Chin-Rang Chen, Lihe Jung, Hyun Jun Park, Euijung Limbutara, Kavee Carter, Benjamin Yang, Zhi-Hong Kun, Julia F. Remaley, Alan T. Knepper, Mark A. Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics |
title | Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics |
title_full | Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics |
title_fullStr | Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics |
title_full_unstemmed | Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics |
title_short | Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics |
title_sort | signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276015/ https://www.ncbi.nlm.nih.gov/pubmed/37328470 http://dx.doi.org/10.1038/s41467-023-38958-9 |
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