Cargando…

Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study

Despite increasing therapeutic options to treat rheumatoid arthritis (RA), many patients fail to reach treatment targets. The use of antidiabetic drugs like thiazolidinediones has been associated with lower RA risk. We aimed to explore the repurposing potential of antidiabetic drugs in RA prevention...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qin, Chenxi, Diaz-Gallo, Lina-Marcela, Tang, Bowen, Wang, Yunzhang, Nguyen, Thuy-Dung, Harder, Arvid, Lu, Yi, Padyukov, Leonid, Askling, Johan, Hägg, Sara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2023
Materias:	Locomotor Diseases
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276071/ https://www.ncbi.nlm.nih.gov/pubmed/37052755 http://dx.doi.org/10.1007/s10654-023-01000-9

Ejemplares similares

Age-specific effects of weight-based body size on fracture risk in later life: a lifecourse Mendelian randomisation study
por: Power, Grace Marion, et al.
Publicado: (2023)

Smoking and susceptibility to rheumatoid arthritis in a Swedish population-based case–control study
por: Hedström, Anna Karin, et al.
Publicado: (2018)

Postmenopausal hormone therapy and the risk of rheumatoid arthritis: results from the Swedish EIRA population-based case-control study
por: Orellana, Cecilia, et al.
Publicado: (2015)

Physical activity and the risk of hip fracture in the elderly: a prospective cohort study
por: Lagerros, Ylva Trolle, et al.
Publicado: (2017)

Low serum magnesium levels are associated with increased risk of fractures: a long-term prospective cohort study
por: Kunutsor, Setor Kwadzo, et al.
Publicado: (2017)

Genetic Variation in Targets of Antidiabetic Drugs and Alzheimer Disease Risk: A Mendelian Randomization Study
por: Tang, Bowen, et al.
Publicado: (2022)

Longitudinal associations between use of antihypertensive, antidiabetic, and lipid-lowering medications and biological aging
por: Tang, Bowen, et al.
Publicado: (2023)

Fatty Acids and Frailty: A Mendelian Randomization Study
por: Tomata, Yasutake, et al.
Publicado: (2021)

Protein Nutritional Status and Frailty: A Mendelian Randomization Study
por: Tomata, Yasutake, et al.
Publicado: (2021)

A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy – results from a Swedish cohort study
por: Jiang, Xia, et al.
Publicado: (2016)

Age at menarche, age at natural menopause, and risk of rheumatoid arthritis — a Mendelian randomization study
por: Zhu, Jingjing, et al.
Publicado: (2021)

Genetics of age-at-onset in major depression
por: Harder, Arvid, et al.
Publicado: (2022)

Occupational inhalable agents constitute major risk factors for rheumatoid arthritis, particularly in the context of genetic predisposition and smoking
por: Tang, Bowen, et al.
Publicado: (2023)

Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses
por: Mak, Jonathan K. L., et al.
Publicado: (2023)

Repurposing Antidiabetic Drugs for Cardiovascular Disease
por: Schubert, Mario, et al.
Publicado: (2020)

Genetics of rheumatoid arthritis
por: Padyukov, Leonid
Publicado: (2022)

Glucocorticoid exposure and the risk of serious infections in rheumatoid arthritis: a marginal structural model application
por: Barbulescu, Andrei, et al.
Publicado: (2023)

Response to Comment “Sex-specific exposures and sex-combined outcomes in two-sample Mendelian randomization may mislead the causal inference” on “Age at menarche, age at natural menopause, and risk of rheumatoid arthritis—a Mendelian randomization study”
por: Zhu, Jingjing, et al.
Publicado: (2022)

Genetically-predicted life-long lowering of low-density lipoprotein cholesterol is associated with decreased frailty: A Mendelian randomization study in UK biobank
por: Wang, Qi, et al.
Publicado: (2019)

Obesity‐Related Traits and the Development of Rheumatoid Arthritis: Evidence From Genetic Data
por: Tang, Bowen, et al.
Publicado: (2020)

Guía para la evaluación y el tratamiento del dolor musculoesquelético /
por: Oteo Álvaro, Ángel
Publicado: (2006)

Systematic approach demonstrates enrichment of multiple interactions between non-HLA risk variants and HLA-DRB1 risk alleles in rheumatoid arthritis
por: Diaz-Gallo, Lina-Marcela, et al.
Publicado: (2018)

Genetic Vectors as a Tool in Association Studies: Definitions and Application for Study of Rheumatoid Arthritis
por: Sandalov, Igor, et al.
Publicado: (2015)

Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs
por: Olatunde, Ahmed, et al.
Publicado: (2021)

Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis
por: Shchetynsky, Klementy, et al.
Publicado: (2017)

Use of Mendelian randomization to better understand and treat sepsis
por: Russell, James A., et al.
Publicado: (2022)

Dynamic patterns of blood lipids and DNA methylation in response to statin therapy
por: Qin, Xueying, et al.
Publicado: (2022)

A phenome-wide bidirectional Mendelian randomization analysis of atrial fibrillation
por: Wang, Qin, et al.
Publicado: (2022)

Repurposing Antihypertensive Drugs for the Prevention of Glaucoma: A Mendelian Randomization Study
por: Liu, Jingjing, et al.
Publicado: (2022)

Genetic liability to insomnia in relation to cardiovascular diseases: a Mendelian randomisation study
por: Yuan, Shuai, et al.
Publicado: (2021)

Evaluation of new or repurposed treatments for COVID-19: protocol for the phase Ib/IIa DEFINE trial platform
por: Gaughan, Erin, et al.
Publicado: (2021)

Siblings of patients with rheumatoid arthritis have an increased mortality rate: a Swedish cohort study
por: Westerlind, Helga, et al.
Publicado: (2020)

Repurposing povidone-iodine to reduce the risk of SARS-CoV-2 infection and transmission: a narrative review
por: Lim, Nicole-Ann, et al.
Publicado: (2022)

Reciprocal interaction between depression and pain: results from a comprehensive bidirectional Mendelian randomization study and functional annotation analysis
por: Tang, Bowen, et al.
Publicado: (2022)

Repurposing antihypertensive drugs for the prevention of Alzheimer’s disease: a Mendelian randomization study
por: Walker, Venexia M, et al.
Publicado: (2019)

PTPN22 splice forms: a new role in rheumatoid arthritis
por: Diaz-Gallo, Lina-Marcela, et al.
Publicado: (2012)

Implementing a method for studying longitudinal DNA methylation variability in association with age
por: Wang, Yunzhang, et al.
Publicado: (2018)

Does autoimmune thyroid disease affects rheumatoid arthritis disease activity or response to methotrexate?
por: Waldenlind, Kristin, et al.
Publicado: (2020)

A Gene–Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis
por: Rivera, Natalia V., et al.
Publicado: (2019)

Risk of breast cancer before and after rheumatoid arthritis, and the impact of hormonal factors
por: Wadström, Hjalmar, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_c3k1sdiplp8umu7ldpppgbk9mh