Hematologic toxicities of chemotherapy in breast and ovarian cancer patients carrying BRCA1/BRCA2 germline pathogenic variants. A single center experience and review of the literature

BRCA1 and BRCA2 play a central role in DNA repair and their germline pathogenic variants (gBRCA) confer a high risk for developing breast and ovarian cancer. Standard chemotherapy regimens for these cancers include DNA-damaging agents. We hypothesized that gBRCA carriers might be at higher risk of d...

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Detalles Bibliográficos
Autores principales: Hu-Heimgartner, Ketty, Lang, Noémie, Ayme, Aurélie, Ming, Chang, Combes, Jean‑Damien, Chappuis, Victor N., Vazquez, Carla, Friedlaender, Alex, Vuilleumier, Aurélie, Bodmer, Alexandre, Viassolo, Valeria, Sandoval, José L, Chappuis, Pierre O., Labidi-Galy, S. Intidhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276105/
https://www.ncbi.nlm.nih.gov/pubmed/37119509
http://dx.doi.org/10.1007/s10689-023-00331-6

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