Medication‐related osteonecrosis of the jaw leading to sepsis in a patient with rheumatoid arthritis: A case report and clinical implications

KEY CLINICAL MESSAGE: Chronic use of bisphosphonates, in combination with immunosuppressive therapy, increases the risk of jaw osteonecrosis. When sepsis occurs in patients receiving bisphosphonate, osteonecrosis of the jaw should be considered a potential source of infection. ABSTRACT: Reports of m...

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Detalles Bibliográficos
Autores principales: Iwasaki, Kazuhiko, Okazaki, Akihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276238/
https://www.ncbi.nlm.nih.gov/pubmed/37334335
http://dx.doi.org/10.1002/ccr3.7588
Descripción
Sumario:KEY CLINICAL MESSAGE: Chronic use of bisphosphonates, in combination with immunosuppressive therapy, increases the risk of jaw osteonecrosis. When sepsis occurs in patients receiving bisphosphonate, osteonecrosis of the jaw should be considered a potential source of infection. ABSTRACT: Reports of medication‐related osteonecrosis of the jaw (MRONJ) accompanied by sepsis are limited. A 75‐year‐old female patient with rheumatoid arthritis, receiving treatment with bisphosphonate and abatacept, developed sepsis secondary to MRONJ. When sepsis occurs in patients receiving bisphosphonate, osteonecrosis of the jaw should be considered a potential source of infection.

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