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Diarylheptanoid 35d overcomes EGFR TKI resistance by inducing hsp70-mediated lysosomal degradation of EGFR in EGFR-mutant lung adenocarcinoma

Epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma (LUAD) patients often respond to EGFR tyrosine kinase inhibitors (TKIs) initially but eventually develop resistance to TKIs. The switch of EGFR downstream signaling from TKI-sensitive to TKI-insensitive is a critical mechanism-drivin...

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Detalles Bibliográficos
Autores principales:	Hong, Xuan, Hsieh, Min-Tsang, Tseng, Tzu-Yu, Lin, Hui-Yi, Chang, Hung-Chih, Yau, Sir-Theng, Cheng, Wei-Chung, Ke, Baozhen, Liao, Hsiao-Hui, Wu, Chih-Ying, Liu, An-An, Wu, Meei-Maan, Huang, Kuo-Yen, Yang, Pan-Chyr, Kuo, Sheng-Chu, Hung, Mien-Chie, Lee, Pei-Chih
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276293/ https://www.ncbi.nlm.nih.gov/pubmed/37178919 http://dx.doi.org/10.1016/j.jbc.2023.104814

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