Non-Coding RNAs Regulate Spinal Cord Injury-Related Neuropathic Pain via Neuroinflammation

Secondary chronic neuropathic pain (NP) in addition to sensory, motor, or autonomic dysfunction can significantly reduce quality of life after spinal cord injury (SCI). The mechanisms of SCI-related NP have been studied in clinical trials and with the use of experimental models. However, in developi...

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Autores principales: Zhu, Jing, Huang, Fei, Hu, Yonglin, Qiao, Wei, Guan, Yingchao, Zhang, Zhi-Jun, Liu, Su, Liu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276590/
https://www.ncbi.nlm.nih.gov/pubmed/37334347
http://dx.doi.org/10.2147/JIR.S413264
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author Zhu, Jing
Huang, Fei
Hu, Yonglin
Qiao, Wei
Guan, Yingchao
Zhang, Zhi-Jun
Liu, Su
Liu, Ying
author_facet Zhu, Jing
Huang, Fei
Hu, Yonglin
Qiao, Wei
Guan, Yingchao
Zhang, Zhi-Jun
Liu, Su
Liu, Ying
author_sort Zhu, Jing
collection PubMed
description Secondary chronic neuropathic pain (NP) in addition to sensory, motor, or autonomic dysfunction can significantly reduce quality of life after spinal cord injury (SCI). The mechanisms of SCI-related NP have been studied in clinical trials and with the use of experimental models. However, in developing new treatment strategies for SCI patients, NP poses new challenges. The inflammatory response following SCI promotes the development of NP. Previous studies suggest that reducing neuroinflammation following SCI can improve NP-related behaviors. Intensive studies of the roles of non-coding RNAs in SCI have discovered that ncRNAs bind target mRNA, act between activated glia, neuronal cells, or other immunocytes, regulate gene expression, inhibit inflammation, and influence the prognosis of NP.
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spelling pubmed-102765902023-06-18 Non-Coding RNAs Regulate Spinal Cord Injury-Related Neuropathic Pain via Neuroinflammation Zhu, Jing Huang, Fei Hu, Yonglin Qiao, Wei Guan, Yingchao Zhang, Zhi-Jun Liu, Su Liu, Ying J Inflamm Res Review Secondary chronic neuropathic pain (NP) in addition to sensory, motor, or autonomic dysfunction can significantly reduce quality of life after spinal cord injury (SCI). The mechanisms of SCI-related NP have been studied in clinical trials and with the use of experimental models. However, in developing new treatment strategies for SCI patients, NP poses new challenges. The inflammatory response following SCI promotes the development of NP. Previous studies suggest that reducing neuroinflammation following SCI can improve NP-related behaviors. Intensive studies of the roles of non-coding RNAs in SCI have discovered that ncRNAs bind target mRNA, act between activated glia, neuronal cells, or other immunocytes, regulate gene expression, inhibit inflammation, and influence the prognosis of NP. Dove 2023-06-13 /pmc/articles/PMC10276590/ /pubmed/37334347 http://dx.doi.org/10.2147/JIR.S413264 Text en © 2023 Zhu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Zhu, Jing
Huang, Fei
Hu, Yonglin
Qiao, Wei
Guan, Yingchao
Zhang, Zhi-Jun
Liu, Su
Liu, Ying
Non-Coding RNAs Regulate Spinal Cord Injury-Related Neuropathic Pain via Neuroinflammation
title Non-Coding RNAs Regulate Spinal Cord Injury-Related Neuropathic Pain via Neuroinflammation
title_full Non-Coding RNAs Regulate Spinal Cord Injury-Related Neuropathic Pain via Neuroinflammation
title_fullStr Non-Coding RNAs Regulate Spinal Cord Injury-Related Neuropathic Pain via Neuroinflammation
title_full_unstemmed Non-Coding RNAs Regulate Spinal Cord Injury-Related Neuropathic Pain via Neuroinflammation
title_short Non-Coding RNAs Regulate Spinal Cord Injury-Related Neuropathic Pain via Neuroinflammation
title_sort non-coding rnas regulate spinal cord injury-related neuropathic pain via neuroinflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276590/
https://www.ncbi.nlm.nih.gov/pubmed/37334347
http://dx.doi.org/10.2147/JIR.S413264
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