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Study of correlation between vitamin D3 levels and dry eye

PURPOSE: Dry eye is a prevalent disorder of tear film resulting from either decreased tear production or increased tear evaporation. It is becoming a serious issue due to its disturbing symptoms, which become progressively troublesome affecting the work efficiency of patients and increasing financia...

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Autores principales: Bhatt, Rupal B, Patel, Naitik H, Shah, Abhishek T, Ranpara, Kaushambi H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276696/
https://www.ncbi.nlm.nih.gov/pubmed/37026286
http://dx.doi.org/10.4103/IJO.IJO_2838_22
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author Bhatt, Rupal B
Patel, Naitik H
Shah, Abhishek T
Ranpara, Kaushambi H
author_facet Bhatt, Rupal B
Patel, Naitik H
Shah, Abhishek T
Ranpara, Kaushambi H
author_sort Bhatt, Rupal B
collection PubMed
description PURPOSE: Dry eye is a prevalent disorder of tear film resulting from either decreased tear production or increased tear evaporation. It is becoming a serious issue due to its disturbing symptoms, which become progressively troublesome affecting the work efficiency of patients and increasing financial burden due to lifelong dependency on eye drops. If not detected early, it can lead to sight-threatening complications. This study aims to explore serum vitamin D3 deficiency as a causative factor of dry eye. METHODS: The study was conducted in the outpatient department of a tertiary care hospital in India, for a period of two years from September 2018 to September 2020. About 40 patients who had dry eye and 20 controls were enrolled in this study. They were given an Ocular Surface Disease Index (OSDI) questionnaire, examined for signs of dry eye on slit lamp with Schirmer’s test and tear film break-up time. All 60 participants were subjected to serum vitamin D3 level laboratory test and its deficiency prevalence was correlated with dry eye and its severity. RESULTS: Serum vitamin D3 deficiency was found to be more prevalent in patients with dry eye. There was no gender predilection or change in prevalence with increasing age. Vitamin D3 level was negatively correlated with OSDI and positively with Schirmer’s test 1 and 2 and tear film break-up time (TBUT) scores. CONCLUSION: The prevalence of vitamin D3 deficiency was not consistently found to be associated with the increasing severity of dry eye.
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spelling pubmed-102766962023-06-18 Study of correlation between vitamin D3 levels and dry eye Bhatt, Rupal B Patel, Naitik H Shah, Abhishek T Ranpara, Kaushambi H Indian J Ophthalmol Original Article PURPOSE: Dry eye is a prevalent disorder of tear film resulting from either decreased tear production or increased tear evaporation. It is becoming a serious issue due to its disturbing symptoms, which become progressively troublesome affecting the work efficiency of patients and increasing financial burden due to lifelong dependency on eye drops. If not detected early, it can lead to sight-threatening complications. This study aims to explore serum vitamin D3 deficiency as a causative factor of dry eye. METHODS: The study was conducted in the outpatient department of a tertiary care hospital in India, for a period of two years from September 2018 to September 2020. About 40 patients who had dry eye and 20 controls were enrolled in this study. They were given an Ocular Surface Disease Index (OSDI) questionnaire, examined for signs of dry eye on slit lamp with Schirmer’s test and tear film break-up time. All 60 participants were subjected to serum vitamin D3 level laboratory test and its deficiency prevalence was correlated with dry eye and its severity. RESULTS: Serum vitamin D3 deficiency was found to be more prevalent in patients with dry eye. There was no gender predilection or change in prevalence with increasing age. Vitamin D3 level was negatively correlated with OSDI and positively with Schirmer’s test 1 and 2 and tear film break-up time (TBUT) scores. CONCLUSION: The prevalence of vitamin D3 deficiency was not consistently found to be associated with the increasing severity of dry eye. Wolters Kluwer - Medknow 2023-04 2023-04-05 /pmc/articles/PMC10276696/ /pubmed/37026286 http://dx.doi.org/10.4103/IJO.IJO_2838_22 Text en Copyright: © 2023 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Bhatt, Rupal B
Patel, Naitik H
Shah, Abhishek T
Ranpara, Kaushambi H
Study of correlation between vitamin D3 levels and dry eye
title Study of correlation between vitamin D3 levels and dry eye
title_full Study of correlation between vitamin D3 levels and dry eye
title_fullStr Study of correlation between vitamin D3 levels and dry eye
title_full_unstemmed Study of correlation between vitamin D3 levels and dry eye
title_short Study of correlation between vitamin D3 levels and dry eye
title_sort study of correlation between vitamin d3 levels and dry eye
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276696/
https://www.ncbi.nlm.nih.gov/pubmed/37026286
http://dx.doi.org/10.4103/IJO.IJO_2838_22
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