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Aqueous-deficient dry eye disease: Preferred practice pattern guidelines on clinical approach, diagnosis, and management
Dry eye disease (DED) is a broad term that includes a diverse group of clinical disorders. Aqueous-deficient dry eye (ADDE), a subtype of DED, is characterized by decreased tear production by the lacrimal gland. It can be seen in up to one-third of individuals with DED and can be comorbid with a sys...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276701/ https://www.ncbi.nlm.nih.gov/pubmed/37026265 http://dx.doi.org/10.4103/IJO.IJO_2808_22 |
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author | Donthineni, Pragnya R Doctor, Mariya B Shanbhag, Swapna Kate, Anahita Galor, Anat Djalilian, Ali R Singh, Swati Basu, Sayan |
author_facet | Donthineni, Pragnya R Doctor, Mariya B Shanbhag, Swapna Kate, Anahita Galor, Anat Djalilian, Ali R Singh, Swati Basu, Sayan |
author_sort | Donthineni, Pragnya R |
collection | PubMed |
description | Dry eye disease (DED) is a broad term that includes a diverse group of clinical disorders. Aqueous-deficient dry eye (ADDE), a subtype of DED, is characterized by decreased tear production by the lacrimal gland. It can be seen in up to one-third of individuals with DED and can be comorbid with a systemic autoimmune process or occur secondary to an environmental insult. Since ADDE can be a source of long-term suffering and severe visual impairment, early identification and adequate treatment are imperative. Multiple etiologies can underlie ADDE, and it is critical to identify the underlying cause to not only improve the ocular health but also to improve the overall quality of life and well-being of affected individuals. This review discusses the various etiologies of ADDE, highlights a pathophysiology-based approach for evaluating underlying contributors, outlines various diagnostic tests, and reviews treatment options. We present the current standards and discuss ongoing research in this field. Through this review, we propose a treatment algorithm that would be useful for an ophthalmologist in diagnosing and managing individuals with ADDE. |
format | Online Article Text |
id | pubmed-10276701 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-102767012023-06-18 Aqueous-deficient dry eye disease: Preferred practice pattern guidelines on clinical approach, diagnosis, and management Donthineni, Pragnya R Doctor, Mariya B Shanbhag, Swapna Kate, Anahita Galor, Anat Djalilian, Ali R Singh, Swati Basu, Sayan Indian J Ophthalmol Preferred Practice Dry eye disease (DED) is a broad term that includes a diverse group of clinical disorders. Aqueous-deficient dry eye (ADDE), a subtype of DED, is characterized by decreased tear production by the lacrimal gland. It can be seen in up to one-third of individuals with DED and can be comorbid with a systemic autoimmune process or occur secondary to an environmental insult. Since ADDE can be a source of long-term suffering and severe visual impairment, early identification and adequate treatment are imperative. Multiple etiologies can underlie ADDE, and it is critical to identify the underlying cause to not only improve the ocular health but also to improve the overall quality of life and well-being of affected individuals. This review discusses the various etiologies of ADDE, highlights a pathophysiology-based approach for evaluating underlying contributors, outlines various diagnostic tests, and reviews treatment options. We present the current standards and discuss ongoing research in this field. Through this review, we propose a treatment algorithm that would be useful for an ophthalmologist in diagnosing and managing individuals with ADDE. Wolters Kluwer - Medknow 2023-04 2023-04-05 /pmc/articles/PMC10276701/ /pubmed/37026265 http://dx.doi.org/10.4103/IJO.IJO_2808_22 Text en Copyright: © 2023 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Preferred Practice Donthineni, Pragnya R Doctor, Mariya B Shanbhag, Swapna Kate, Anahita Galor, Anat Djalilian, Ali R Singh, Swati Basu, Sayan Aqueous-deficient dry eye disease: Preferred practice pattern guidelines on clinical approach, diagnosis, and management |
title | Aqueous-deficient dry eye disease: Preferred practice pattern guidelines on clinical approach, diagnosis, and management |
title_full | Aqueous-deficient dry eye disease: Preferred practice pattern guidelines on clinical approach, diagnosis, and management |
title_fullStr | Aqueous-deficient dry eye disease: Preferred practice pattern guidelines on clinical approach, diagnosis, and management |
title_full_unstemmed | Aqueous-deficient dry eye disease: Preferred practice pattern guidelines on clinical approach, diagnosis, and management |
title_short | Aqueous-deficient dry eye disease: Preferred practice pattern guidelines on clinical approach, diagnosis, and management |
title_sort | aqueous-deficient dry eye disease: preferred practice pattern guidelines on clinical approach, diagnosis, and management |
topic | Preferred Practice |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276701/ https://www.ncbi.nlm.nih.gov/pubmed/37026265 http://dx.doi.org/10.4103/IJO.IJO_2808_22 |
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