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A review of rabbit models of meibomian gland dysfunction and scope for translational research
Dry eye disease (DED) is an emerging global health concern with meibomian gland dysfunction (MGD) being the most common subtype of DED. Despite being quite prevalent, the pathophysiological mechanisms governing MGD are poorly understood. Animal models for MGD can be a valuable resource to advance ou...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276725/ https://www.ncbi.nlm.nih.gov/pubmed/37026253 http://dx.doi.org/10.4103/IJO.IJO_2815_22 |
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author | Prasad, Deeksha Salman, Mohd Reddy, A Aniruth Jaffet, Jilu Sahoo, Abhishek Jakati, Saumya Bokara, Kiran Kumar Singh, Swati Basu, Sayan Singh, Vivek Donthineni, Pragnya Rao |
author_facet | Prasad, Deeksha Salman, Mohd Reddy, A Aniruth Jaffet, Jilu Sahoo, Abhishek Jakati, Saumya Bokara, Kiran Kumar Singh, Swati Basu, Sayan Singh, Vivek Donthineni, Pragnya Rao |
author_sort | Prasad, Deeksha |
collection | PubMed |
description | Dry eye disease (DED) is an emerging global health concern with meibomian gland dysfunction (MGD) being the most common subtype of DED. Despite being quite prevalent, the pathophysiological mechanisms governing MGD are poorly understood. Animal models for MGD can be a valuable resource to advance our understanding of this entity and explore novel diagnostic and therapeutic modalities. Although a lot of literature on rodent MGD models exists, a comprehensive review on rabbit animal models is lacking. Rabbits offer a great advantage over other animals as models for studying both DED and MGD. Rabbits have a widely exposed ocular surface and meibomian gland anatomy comparable with humans, which makes performing dry eye diagnostic tests possible using clinically validated imaging platforms. The existing MGD models in rabbits can broadly be classified as pharmacologically induced and surgically induced models. Most models show keratinization of the meibomian gland orifice with plugging as the final common pathway for developing MGD. Thus, understanding the advantages and disadvantages of each rabbit MGD model can help researchers choose the appropriate experimental plan based on the objective of the study. In this review, we discuss the comparative anatomy of the meibomian glands in humans and rabbits, various rabbit models of MGD, translational applications, unmet needs, and future directions in developing MGD models in rabbits. |
format | Online Article Text |
id | pubmed-10276725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-102767252023-06-18 A review of rabbit models of meibomian gland dysfunction and scope for translational research Prasad, Deeksha Salman, Mohd Reddy, A Aniruth Jaffet, Jilu Sahoo, Abhishek Jakati, Saumya Bokara, Kiran Kumar Singh, Swati Basu, Sayan Singh, Vivek Donthineni, Pragnya Rao Indian J Ophthalmol Review Article - Basic Sciences and Applied Research Dry eye disease (DED) is an emerging global health concern with meibomian gland dysfunction (MGD) being the most common subtype of DED. Despite being quite prevalent, the pathophysiological mechanisms governing MGD are poorly understood. Animal models for MGD can be a valuable resource to advance our understanding of this entity and explore novel diagnostic and therapeutic modalities. Although a lot of literature on rodent MGD models exists, a comprehensive review on rabbit animal models is lacking. Rabbits offer a great advantage over other animals as models for studying both DED and MGD. Rabbits have a widely exposed ocular surface and meibomian gland anatomy comparable with humans, which makes performing dry eye diagnostic tests possible using clinically validated imaging platforms. The existing MGD models in rabbits can broadly be classified as pharmacologically induced and surgically induced models. Most models show keratinization of the meibomian gland orifice with plugging as the final common pathway for developing MGD. Thus, understanding the advantages and disadvantages of each rabbit MGD model can help researchers choose the appropriate experimental plan based on the objective of the study. In this review, we discuss the comparative anatomy of the meibomian glands in humans and rabbits, various rabbit models of MGD, translational applications, unmet needs, and future directions in developing MGD models in rabbits. Wolters Kluwer - Medknow 2023-04 2023-04-05 /pmc/articles/PMC10276725/ /pubmed/37026253 http://dx.doi.org/10.4103/IJO.IJO_2815_22 Text en Copyright: © 2023 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article - Basic Sciences and Applied Research Prasad, Deeksha Salman, Mohd Reddy, A Aniruth Jaffet, Jilu Sahoo, Abhishek Jakati, Saumya Bokara, Kiran Kumar Singh, Swati Basu, Sayan Singh, Vivek Donthineni, Pragnya Rao A review of rabbit models of meibomian gland dysfunction and scope for translational research |
title | A review of rabbit models of meibomian gland dysfunction and scope for translational research |
title_full | A review of rabbit models of meibomian gland dysfunction and scope for translational research |
title_fullStr | A review of rabbit models of meibomian gland dysfunction and scope for translational research |
title_full_unstemmed | A review of rabbit models of meibomian gland dysfunction and scope for translational research |
title_short | A review of rabbit models of meibomian gland dysfunction and scope for translational research |
title_sort | review of rabbit models of meibomian gland dysfunction and scope for translational research |
topic | Review Article - Basic Sciences and Applied Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276725/ https://www.ncbi.nlm.nih.gov/pubmed/37026253 http://dx.doi.org/10.4103/IJO.IJO_2815_22 |
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