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Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface
Dry eye disease (DED) is a chronic ocular surface disorder, associated with inflammation, which can cause severe morbidity, visual compromise, and loss of quality of life, affecting up to 5–50% of the world population. In DED, ocular surface damage and tear film instability due to abnormal tear secr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276742/ https://www.ncbi.nlm.nih.gov/pubmed/37026260 http://dx.doi.org/10.4103/IJO.IJO_2912_22 |
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author | Jeyabalan, Nallathambi Pillai, Aswathi M Khamar, Pooja Shetty, Rohit Mohan, Rajiv R Ghosh, Arkasubhra |
author_facet | Jeyabalan, Nallathambi Pillai, Aswathi M Khamar, Pooja Shetty, Rohit Mohan, Rajiv R Ghosh, Arkasubhra |
author_sort | Jeyabalan, Nallathambi |
collection | PubMed |
description | Dry eye disease (DED) is a chronic ocular surface disorder, associated with inflammation, which can cause severe morbidity, visual compromise, and loss of quality of life, affecting up to 5–50% of the world population. In DED, ocular surface damage and tear film instability due to abnormal tear secretion lead to ocular surface pain, discomfort, and epithelial barrier disruption. Studies have shown the involvement of autophagy regulation in dry eye disease as a pathogenic mechanism along with the inflammatory response. Autophagy is a self-degradation pathway in mammalian cells that reduces the excessive inflammation driven by the secretion of inflammatory factors in tears. Specific autophagy modulators are already available for the management of DED currently. However, growing studies on autophagy regulation in DED might further encourage the development of autophagy modulating drugs that reduce the pathological response at the ocular surface. In this review, we summarize the role of autophagy in the pathogenesis of dry eye disease and explore its therapeutic application. |
format | Online Article Text |
id | pubmed-10276742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-102767422023-06-18 Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface Jeyabalan, Nallathambi Pillai, Aswathi M Khamar, Pooja Shetty, Rohit Mohan, Rajiv R Ghosh, Arkasubhra Indian J Ophthalmol Review Article - Basic Sciences and Applied Research Dry eye disease (DED) is a chronic ocular surface disorder, associated with inflammation, which can cause severe morbidity, visual compromise, and loss of quality of life, affecting up to 5–50% of the world population. In DED, ocular surface damage and tear film instability due to abnormal tear secretion lead to ocular surface pain, discomfort, and epithelial barrier disruption. Studies have shown the involvement of autophagy regulation in dry eye disease as a pathogenic mechanism along with the inflammatory response. Autophagy is a self-degradation pathway in mammalian cells that reduces the excessive inflammation driven by the secretion of inflammatory factors in tears. Specific autophagy modulators are already available for the management of DED currently. However, growing studies on autophagy regulation in DED might further encourage the development of autophagy modulating drugs that reduce the pathological response at the ocular surface. In this review, we summarize the role of autophagy in the pathogenesis of dry eye disease and explore its therapeutic application. Wolters Kluwer - Medknow 2023-04 2023-04-05 /pmc/articles/PMC10276742/ /pubmed/37026260 http://dx.doi.org/10.4103/IJO.IJO_2912_22 Text en Copyright: © 2023 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article - Basic Sciences and Applied Research Jeyabalan, Nallathambi Pillai, Aswathi M Khamar, Pooja Shetty, Rohit Mohan, Rajiv R Ghosh, Arkasubhra Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface |
title | Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface |
title_full | Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface |
title_fullStr | Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface |
title_full_unstemmed | Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface |
title_short | Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface |
title_sort | autophagy in dry eye disease: therapeutic implications of autophagy modulators on the ocular surface |
topic | Review Article - Basic Sciences and Applied Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276742/ https://www.ncbi.nlm.nih.gov/pubmed/37026260 http://dx.doi.org/10.4103/IJO.IJO_2912_22 |
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