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Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface

Dry eye disease (DED) is a chronic ocular surface disorder, associated with inflammation, which can cause severe morbidity, visual compromise, and loss of quality of life, affecting up to 5–50% of the world population. In DED, ocular surface damage and tear film instability due to abnormal tear secr...

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Autores principales: Jeyabalan, Nallathambi, Pillai, Aswathi M, Khamar, Pooja, Shetty, Rohit, Mohan, Rajiv R, Ghosh, Arkasubhra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276742/
https://www.ncbi.nlm.nih.gov/pubmed/37026260
http://dx.doi.org/10.4103/IJO.IJO_2912_22
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author Jeyabalan, Nallathambi
Pillai, Aswathi M
Khamar, Pooja
Shetty, Rohit
Mohan, Rajiv R
Ghosh, Arkasubhra
author_facet Jeyabalan, Nallathambi
Pillai, Aswathi M
Khamar, Pooja
Shetty, Rohit
Mohan, Rajiv R
Ghosh, Arkasubhra
author_sort Jeyabalan, Nallathambi
collection PubMed
description Dry eye disease (DED) is a chronic ocular surface disorder, associated with inflammation, which can cause severe morbidity, visual compromise, and loss of quality of life, affecting up to 5–50% of the world population. In DED, ocular surface damage and tear film instability due to abnormal tear secretion lead to ocular surface pain, discomfort, and epithelial barrier disruption. Studies have shown the involvement of autophagy regulation in dry eye disease as a pathogenic mechanism along with the inflammatory response. Autophagy is a self-degradation pathway in mammalian cells that reduces the excessive inflammation driven by the secretion of inflammatory factors in tears. Specific autophagy modulators are already available for the management of DED currently. However, growing studies on autophagy regulation in DED might further encourage the development of autophagy modulating drugs that reduce the pathological response at the ocular surface. In this review, we summarize the role of autophagy in the pathogenesis of dry eye disease and explore its therapeutic application.
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spelling pubmed-102767422023-06-18 Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface Jeyabalan, Nallathambi Pillai, Aswathi M Khamar, Pooja Shetty, Rohit Mohan, Rajiv R Ghosh, Arkasubhra Indian J Ophthalmol Review Article - Basic Sciences and Applied Research Dry eye disease (DED) is a chronic ocular surface disorder, associated with inflammation, which can cause severe morbidity, visual compromise, and loss of quality of life, affecting up to 5–50% of the world population. In DED, ocular surface damage and tear film instability due to abnormal tear secretion lead to ocular surface pain, discomfort, and epithelial barrier disruption. Studies have shown the involvement of autophagy regulation in dry eye disease as a pathogenic mechanism along with the inflammatory response. Autophagy is a self-degradation pathway in mammalian cells that reduces the excessive inflammation driven by the secretion of inflammatory factors in tears. Specific autophagy modulators are already available for the management of DED currently. However, growing studies on autophagy regulation in DED might further encourage the development of autophagy modulating drugs that reduce the pathological response at the ocular surface. In this review, we summarize the role of autophagy in the pathogenesis of dry eye disease and explore its therapeutic application. Wolters Kluwer - Medknow 2023-04 2023-04-05 /pmc/articles/PMC10276742/ /pubmed/37026260 http://dx.doi.org/10.4103/IJO.IJO_2912_22 Text en Copyright: © 2023 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article - Basic Sciences and Applied Research
Jeyabalan, Nallathambi
Pillai, Aswathi M
Khamar, Pooja
Shetty, Rohit
Mohan, Rajiv R
Ghosh, Arkasubhra
Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface
title Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface
title_full Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface
title_fullStr Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface
title_full_unstemmed Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface
title_short Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface
title_sort autophagy in dry eye disease: therapeutic implications of autophagy modulators on the ocular surface
topic Review Article - Basic Sciences and Applied Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276742/
https://www.ncbi.nlm.nih.gov/pubmed/37026260
http://dx.doi.org/10.4103/IJO.IJO_2912_22
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