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Tear proteomics in dry eye disease

Dry eye disease (DED) is a multi-factorial ocular surface condition driven by compromised ocular lubrication and inflammation which leads to itching, dryness, and vision impairment. The available treatment modalities primarily target the acquired symptoms of DED including tear film supplements, anti...

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Autores principales: Kannan, Ramaraj, Das, Samayitree, Shetty, Rohit, Zhou, Lei, Ghosh, Arkasubhra, Deshpande, Vrushali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276753/
https://www.ncbi.nlm.nih.gov/pubmed/37026251
http://dx.doi.org/10.4103/IJO.IJO_2851_22
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author Kannan, Ramaraj
Das, Samayitree
Shetty, Rohit
Zhou, Lei
Ghosh, Arkasubhra
Deshpande, Vrushali
author_facet Kannan, Ramaraj
Das, Samayitree
Shetty, Rohit
Zhou, Lei
Ghosh, Arkasubhra
Deshpande, Vrushali
author_sort Kannan, Ramaraj
collection PubMed
description Dry eye disease (DED) is a multi-factorial ocular surface condition driven by compromised ocular lubrication and inflammation which leads to itching, dryness, and vision impairment. The available treatment modalities primarily target the acquired symptoms of DED including tear film supplements, anti-inflammatory drugs, mucin secretagogues, etc., However, the underlying etiology is still an area of active research, especially in regard to the diverse etiology and symptoms. Proteomics is a robust approach that has been playing major role in understanding the causative mechanism and biochemical changes in DED by identifying the changes in protein expression profile in tears. Tears are a complex fluid composed of several biomolecules such as proteins, peptides, lipids, mucins, and metabolites secreted from lacrimal gland, meibomian gland, cornea, and vascular sources. Over the past two decades, tears have emerged as a bona-fide source for biomarker identification in many ocular conditions because of the minimally invasive and simple sample collection procedure. However, the tear proteome can be altered by several factors, which increases the complexity of the approach. The recent advancements in untargeted mass spectrometry-based proteomics could overcome such shortcomings. Also, these technological advancements help to distinguish the DED profiles based on its association with other complications such as Sjogren’s syndrome, rheumatoid arthritis, diabetes, and meibomian gland dysfunction. This review summarizes the important molecular profiles found in proteomics studies to be altered in DED which have added to the understanding of its pathogenesis.
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spelling pubmed-102767532023-06-18 Tear proteomics in dry eye disease Kannan, Ramaraj Das, Samayitree Shetty, Rohit Zhou, Lei Ghosh, Arkasubhra Deshpande, Vrushali Indian J Ophthalmol Review Article - Basic Sciences and Applied Research Dry eye disease (DED) is a multi-factorial ocular surface condition driven by compromised ocular lubrication and inflammation which leads to itching, dryness, and vision impairment. The available treatment modalities primarily target the acquired symptoms of DED including tear film supplements, anti-inflammatory drugs, mucin secretagogues, etc., However, the underlying etiology is still an area of active research, especially in regard to the diverse etiology and symptoms. Proteomics is a robust approach that has been playing major role in understanding the causative mechanism and biochemical changes in DED by identifying the changes in protein expression profile in tears. Tears are a complex fluid composed of several biomolecules such as proteins, peptides, lipids, mucins, and metabolites secreted from lacrimal gland, meibomian gland, cornea, and vascular sources. Over the past two decades, tears have emerged as a bona-fide source for biomarker identification in many ocular conditions because of the minimally invasive and simple sample collection procedure. However, the tear proteome can be altered by several factors, which increases the complexity of the approach. The recent advancements in untargeted mass spectrometry-based proteomics could overcome such shortcomings. Also, these technological advancements help to distinguish the DED profiles based on its association with other complications such as Sjogren’s syndrome, rheumatoid arthritis, diabetes, and meibomian gland dysfunction. This review summarizes the important molecular profiles found in proteomics studies to be altered in DED which have added to the understanding of its pathogenesis. Wolters Kluwer - Medknow 2023-04 2023-04-05 /pmc/articles/PMC10276753/ /pubmed/37026251 http://dx.doi.org/10.4103/IJO.IJO_2851_22 Text en Copyright: © 2023 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article - Basic Sciences and Applied Research
Kannan, Ramaraj
Das, Samayitree
Shetty, Rohit
Zhou, Lei
Ghosh, Arkasubhra
Deshpande, Vrushali
Tear proteomics in dry eye disease
title Tear proteomics in dry eye disease
title_full Tear proteomics in dry eye disease
title_fullStr Tear proteomics in dry eye disease
title_full_unstemmed Tear proteomics in dry eye disease
title_short Tear proteomics in dry eye disease
title_sort tear proteomics in dry eye disease
topic Review Article - Basic Sciences and Applied Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276753/
https://www.ncbi.nlm.nih.gov/pubmed/37026251
http://dx.doi.org/10.4103/IJO.IJO_2851_22
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AT deshpandevrushali tearproteomicsindryeyedisease