Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4(+) T cell fate

Follicular helper T (Tfh) cells are essential for germinal center (GC) B cell responses. However, it is not clear which PD-1(+)CXCR5(+)Bcl6(+)CD4(+) T cells will differentiate into PD-1(hi)CXCR5(hi)Bcl6(hi) GC-Tfh cells and how GC-Tfh cell differentiation is regulated. Here, we report that the susta...

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Detalles Bibliográficos
Autores principales: Zhu, Fangming, McMonigle, Ryan J., Schroeder, Andrew R., Xia, Xianyou, Figge, David, Greer, Braxton D., González-Avalos, Edahí, Sialer, Diego O., Wang, Yin-Hu, Chandler, Kelly M., Getzler, Adam J., Brown, Emily R., Xiao, Changchun, Kutsch, Olaf, Harada, Yohsuke, Pipkin, Matthew E., Hu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276816/
https://www.ncbi.nlm.nih.gov/pubmed/37330549
http://dx.doi.org/10.1038/s41467-023-39299-3

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