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Exploration of the optimal GS-441524 trough concentration for treating COVID-19

OBJECTIVES: Remdesivir (RDV) is the cornerstone for treating coronavirus disease 2019 (COVID-19). The active metabolite of RDV, GS-441524 (a nucleoside analog), has high inter-individual variability in plasma concentration; however, its concentration-response relationship is still unclear. This stud...

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Detalles Bibliográficos
Autores principales:	Nakano, Yuki, Inokuchi, Yoko, Hayama, Tadashi, Hirai, Toshinori, Nishiyama, Mamoru, Sueyasu, Yoshiko, Yokoo, Kenjo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd and International Society of Antimicrobial Chemotherapy. 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276898/ https://www.ncbi.nlm.nih.gov/pubmed/37339712 http://dx.doi.org/10.1016/j.ijantimicag.2023.106892

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