Cargando…

Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology

Tau deposits in astrocytes are frequently found in Alzheimer’s disease (AD) and other tauopathies. Since astrocytes do not express tau, the inclusions have been suggested to be of neuronal origin. However, the mechanisms behind their appearance and their relevance for disease progression remain unkn...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mothes, Tobias, Portal, Benjamin, Konstantinidis, Evangelos, Eltom, Khalid, Libard, Sylwia, Streubel-Gallasch, Linn, Ingelsson, Martin, Rostami, Jinar, Lindskog, Maria, Erlandsson, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276914/ https://www.ncbi.nlm.nih.gov/pubmed/37330529 http://dx.doi.org/10.1186/s40478-023-01589-8

Ejemplares similares

Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function
por: Konstantinidis, Evangelos, et al.
Publicado: (2023)

Extracellular vesicles from amyloid-β exposed cell cultures induce severe dysfunction in cortical neurons
por: Beretta, Chiara, et al.
Publicado: (2020)

Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates
por: Rostami, Jinar, et al.
Publicado: (2021)

Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes
por: Rostami, Jinar, et al.
Publicado: (2017)

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
por: Gustafsson, Gabriel, et al.
Publicado: (2017)

Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson’s disease brain
por: Rostami, Jinar, et al.
Publicado: (2020)

Traumatic brain injury in the presence of Aβ pathology affects neuronal survival, glial activation and autophagy
por: Streubel-Gallasch, Linn, et al.
Publicado: (2021)

The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death
por: Söllvander, Sofia, et al.
Publicado: (2018)

CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer’s disease PSEN1 M146L mutation
por: Konstantinidis, Evangelos, et al.
Publicado: (2022)

Parkinson’s Disease–Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance
por: Streubel-Gallasch, Linn, et al.
Publicado: (2021)

The corpse in the snowman
por: Blake, Nicholas, 1904-1972

Maigret and the headless corpse
por: Simenon, Georges, 1903-1989
Publicado: (1967)

Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation
por: Libard, Sylwia, et al.
Publicado: (2022)

Efferocytosis: Burying cell corpses to regulate tolerance and immunity
por: Divangahi, Maziar
Publicado: (2015)

A perfect funeral with no corpse
por: Earnshaw, William C., et al.
Publicado: (2003)

Corpse Management in Social Insects
por: Sun, Qian, et al.
Publicado: (2013)

COVID-19 and management of the corpse
por: Joob, Beuy, et al.
Publicado: (2020)

Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo
por: Damisah, Eyiyemisi C., et al.
Publicado: (2020)

Tool use for corpse cleaning in chimpanzees
por: van Leeuwen, Edwin J. C., et al.
Publicado: (2017)

The dignity of the human corpse in forensic medicine
por: Schwarz, Clara-Sophie, et al.
Publicado: (2021)

Plague Transmission from Corpses and Carcasses
por: Jullien, Sophie, et al.
Publicado: (2021)

Cell organelles are retained inside pyroptotic corpses during inflammatory cell death
por: Hempel, Anne, et al.
Publicado: (2023)

Curious afterlives: the enduring appeal of the criminal corpse
por: Tarlow, Sarah
Publicado: (2016)

Microglial Corpse Clearance: Lessons From Macrophages
por: Márquez-Ropero, Mar, et al.
Publicado: (2020)

Worm corpses affect quantification of dauer recovery
por: Gabaldon, Carolaing, et al.
Publicado: (2019)

Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell
por: Li, Wei, et al.
Publicado: (2012)

Procuring Corpses: The English Anatomy Inspectorate, 1842 to 1858
por: MacDONALD, HELEN
Publicado: (2009)

Management of corpses during the COVID-19 pandemic in Spain()
por: González-Fernández, Jorge, et al.
Publicado: (2020)

The Complete Genome Sequence of Amorphophallus titanum, the Corpse Flower
por: Frisse, Linda, et al.
Publicado: (2022)

Corpses in Clinical Space and the Preposterous Temporality of Pandemic Care
por: Aboii, Sheyda M.
Publicado: (2023)

Systemic Lupus Erythematosus Presenting as Walking Corpse Syndrome
por: Luma, Barbara, et al.
Publicado: (2023)

Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism
por: Zyśk, Marlena, et al.
Publicado: (2023)

Alzheimer’s disease neuropathological change and loss of matrix/neuropil in patients with idiopathic Normal Pressure Hydrocephalus, a model of Alzheimer’s disease
por: Libard, Sylwia, et al.
Publicado: (2019)

Keep the nest clean: survival advantages of corpse removal in ants
por: Diez, Lise, et al.
Publicado: (2014)

Components of the Engulfment Machinery Have Distinct Roles in Corpse Processing
por: Meehan, Tracy L., et al.
Publicado: (2016)

Macrocheles species (Acari: Macrochelidae) associated with human corpses in Europe
por: Kamaruzaman, Naila A. Che, et al.
Publicado: (2018)

Neisseria meningitides Can Survive in Corpses for At Least Eleven Days
por: Osculati, Antonio, et al.
Publicado: (2016)

No-Touch Automated Room Disinfection after Autopsies of Exhumed Corpses
por: Tarka, Patryk, et al.
Publicado: (2020)

Review: The safe handling of a corpse (suspected) with COVID-19
por: Dijkhuizen, L.G.M., et al.
Publicado: (2020)

Detection and infectivity of SARS-CoV-2 in exhumated corpses
por: Plenzig, S., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3o5fm8i8tlbvqqm4b96u6l1c52