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Invasive Acantholytic Ocular Surface Squamous Neoplasia: A Rare Case

Ocular surface squamous neoplasia (OSSN) is a spectrum of intraepithelial and invasive neoplastic lesions of the conjunctiva and cornea. OSSN is a rare but potentially sight-threatening ocular malignancy that can be challenging to diagnose due to its clinical and histopathological resemblance to ben...

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Autores principales: Sharma, Avi, Daigavane, Sachin, Bhake, Arvind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276922/
https://www.ncbi.nlm.nih.gov/pubmed/37337502
http://dx.doi.org/10.7759/cureus.39219
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author Sharma, Avi
Daigavane, Sachin
Bhake, Arvind
author_facet Sharma, Avi
Daigavane, Sachin
Bhake, Arvind
author_sort Sharma, Avi
collection PubMed
description Ocular surface squamous neoplasia (OSSN) is a spectrum of intraepithelial and invasive neoplastic lesions of the conjunctiva and cornea. OSSN is a rare but potentially sight-threatening ocular malignancy that can be challenging to diagnose due to its clinical and histopathological resemblance to benign ocular surface lesions. However, OSSN can lead to significant ocular and systemic morbidity, including vision loss and metastasis. Various risk factors have been identified, including ultraviolet radiation exposure, human papillomavirus infection, and immunosuppression. The histopathological analysis of the lesion is of utmost importance in diagnosing and further managing squamous cell carcinoma. The acantholytic variant of squamous cell carcinoma is uncommon. Here, we present the case of a 69-year-old male who presented with an invasive mass of progressive growth on the left eyeball extending into the visual axis. The patient underwent extended enucleation, and a histopathological analysis demonstrated a rare acantholytic variant of squamous cell carcinoma.
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spelling pubmed-102769222023-06-19 Invasive Acantholytic Ocular Surface Squamous Neoplasia: A Rare Case Sharma, Avi Daigavane, Sachin Bhake, Arvind Cureus Ophthalmology Ocular surface squamous neoplasia (OSSN) is a spectrum of intraepithelial and invasive neoplastic lesions of the conjunctiva and cornea. OSSN is a rare but potentially sight-threatening ocular malignancy that can be challenging to diagnose due to its clinical and histopathological resemblance to benign ocular surface lesions. However, OSSN can lead to significant ocular and systemic morbidity, including vision loss and metastasis. Various risk factors have been identified, including ultraviolet radiation exposure, human papillomavirus infection, and immunosuppression. The histopathological analysis of the lesion is of utmost importance in diagnosing and further managing squamous cell carcinoma. The acantholytic variant of squamous cell carcinoma is uncommon. Here, we present the case of a 69-year-old male who presented with an invasive mass of progressive growth on the left eyeball extending into the visual axis. The patient underwent extended enucleation, and a histopathological analysis demonstrated a rare acantholytic variant of squamous cell carcinoma. Cureus 2023-05-19 /pmc/articles/PMC10276922/ /pubmed/37337502 http://dx.doi.org/10.7759/cureus.39219 Text en Copyright © 2023, Sharma et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Ophthalmology
Sharma, Avi
Daigavane, Sachin
Bhake, Arvind
Invasive Acantholytic Ocular Surface Squamous Neoplasia: A Rare Case
title Invasive Acantholytic Ocular Surface Squamous Neoplasia: A Rare Case
title_full Invasive Acantholytic Ocular Surface Squamous Neoplasia: A Rare Case
title_fullStr Invasive Acantholytic Ocular Surface Squamous Neoplasia: A Rare Case
title_full_unstemmed Invasive Acantholytic Ocular Surface Squamous Neoplasia: A Rare Case
title_short Invasive Acantholytic Ocular Surface Squamous Neoplasia: A Rare Case
title_sort invasive acantholytic ocular surface squamous neoplasia: a rare case
topic Ophthalmology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276922/
https://www.ncbi.nlm.nih.gov/pubmed/37337502
http://dx.doi.org/10.7759/cureus.39219
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