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Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group
OBJECTIVES: To better define the spectrum of new-onset post-COVID-19 and post-COVID-19 vaccine inflammatory rheumatic diseases (IRD) from a large multicentric observational study. METHODS: Consecutive cases of IRD encountered during a 12-month period and satisfying one of the following inclusion cri...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276969/ https://www.ncbi.nlm.nih.gov/pubmed/37328292 http://dx.doi.org/10.1136/rmdopen-2023-003022 |
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author | Ursini, Francesco Ruscitti, Piero Addimanda, Olga Foti, Rosario Raimondo, Vincenzo Murdaca, Giuseppe Caira, Virginia Pigatto, Erika Cuomo, Giovanna Lo Gullo, Alberto Cavazzana, Ilaria Campochiaro, Corrado Naclerio, Caterina De Angelis, Rossella Ciaffi, Jacopo Mancarella, Luana Brusi, Veronica Marchetti, Elena Motta, Francesca Visentini, Marcella Lorusso, Sebastiano De Santis, Maria De Luca, Giacomo Massaro, Laura Olivo, Domenico Pellegrini, Roberta Francioso, Francesca Luppino, Jessica Di Cola, Ilenia Foti, Roberta Varcasia, Giuseppe Caso, Francesco Reta, Massimo Dagna, Lorenzo Selmi, Carlo Iagnocco, Annamaria Giacomelli, Roberto Iannone, Florenzo Ferri, Clodoveo |
author_facet | Ursini, Francesco Ruscitti, Piero Addimanda, Olga Foti, Rosario Raimondo, Vincenzo Murdaca, Giuseppe Caira, Virginia Pigatto, Erika Cuomo, Giovanna Lo Gullo, Alberto Cavazzana, Ilaria Campochiaro, Corrado Naclerio, Caterina De Angelis, Rossella Ciaffi, Jacopo Mancarella, Luana Brusi, Veronica Marchetti, Elena Motta, Francesca Visentini, Marcella Lorusso, Sebastiano De Santis, Maria De Luca, Giacomo Massaro, Laura Olivo, Domenico Pellegrini, Roberta Francioso, Francesca Luppino, Jessica Di Cola, Ilenia Foti, Roberta Varcasia, Giuseppe Caso, Francesco Reta, Massimo Dagna, Lorenzo Selmi, Carlo Iagnocco, Annamaria Giacomelli, Roberto Iannone, Florenzo Ferri, Clodoveo |
author_sort | Ursini, Francesco |
collection | PubMed |
description | OBJECTIVES: To better define the spectrum of new-onset post-COVID-19 and post-COVID-19 vaccine inflammatory rheumatic diseases (IRD) from a large multicentric observational study. METHODS: Consecutive cases of IRD encountered during a 12-month period and satisfying one of the following inclusion criteria: (a) onset of the rheumatic manifestations within 4 weeks from SARS-CoV-2 infection or (b) onset of the rheumatic manifestations within 4 weeks from the administration of one of the COVID-19 vaccines ws recruited. RESULTS: The final analysis cohort comprised 267 patients, of which 122 (45.2%) in the post-COVID-19 and 145 (54.8%) in the postvaccine cohort. Distribution of IRD categories differed between the two cohorts: the post-COVID-19 cohort had a higher percentage of patients classified as having inflammatory joint diseases (IJD, 52.5% vs 37.2%, p=0.013) while the post-vaccine cohort had a higher prevalence of patients classified as polymyalgia rheumatica (PMR, 33.1% vs 21.3%, p=0.032). No differences were detected in the percentage of patients diagnosed with connective tissue diseases (CTD 19.7% vs 20.7%, p=0.837) or vasculitis (6.6% vs 9.0%, p=0.467). Despite the short follow-up period, IJD and PMR patients’ response to first-line therapy was favourable, with both groups achieving a drop in baseline disease activity scores of ~30% and ~70% respectively. CONCLUSION: Our article reports the largest cohort published to date of new-onset IRD following SARS-CoV-2 infection or COVID-19 vaccines. Although causality cannot be ascertained, the spectrum of possible clinical manifestations is broad and includes IJD, PMR, CTD and vasculitis. |
format | Online Article Text |
id | pubmed-10276969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-102769692023-06-19 Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group Ursini, Francesco Ruscitti, Piero Addimanda, Olga Foti, Rosario Raimondo, Vincenzo Murdaca, Giuseppe Caira, Virginia Pigatto, Erika Cuomo, Giovanna Lo Gullo, Alberto Cavazzana, Ilaria Campochiaro, Corrado Naclerio, Caterina De Angelis, Rossella Ciaffi, Jacopo Mancarella, Luana Brusi, Veronica Marchetti, Elena Motta, Francesca Visentini, Marcella Lorusso, Sebastiano De Santis, Maria De Luca, Giacomo Massaro, Laura Olivo, Domenico Pellegrini, Roberta Francioso, Francesca Luppino, Jessica Di Cola, Ilenia Foti, Roberta Varcasia, Giuseppe Caso, Francesco Reta, Massimo Dagna, Lorenzo Selmi, Carlo Iagnocco, Annamaria Giacomelli, Roberto Iannone, Florenzo Ferri, Clodoveo RMD Open Miscellaneous OBJECTIVES: To better define the spectrum of new-onset post-COVID-19 and post-COVID-19 vaccine inflammatory rheumatic diseases (IRD) from a large multicentric observational study. METHODS: Consecutive cases of IRD encountered during a 12-month period and satisfying one of the following inclusion criteria: (a) onset of the rheumatic manifestations within 4 weeks from SARS-CoV-2 infection or (b) onset of the rheumatic manifestations within 4 weeks from the administration of one of the COVID-19 vaccines ws recruited. RESULTS: The final analysis cohort comprised 267 patients, of which 122 (45.2%) in the post-COVID-19 and 145 (54.8%) in the postvaccine cohort. Distribution of IRD categories differed between the two cohorts: the post-COVID-19 cohort had a higher percentage of patients classified as having inflammatory joint diseases (IJD, 52.5% vs 37.2%, p=0.013) while the post-vaccine cohort had a higher prevalence of patients classified as polymyalgia rheumatica (PMR, 33.1% vs 21.3%, p=0.032). No differences were detected in the percentage of patients diagnosed with connective tissue diseases (CTD 19.7% vs 20.7%, p=0.837) or vasculitis (6.6% vs 9.0%, p=0.467). Despite the short follow-up period, IJD and PMR patients’ response to first-line therapy was favourable, with both groups achieving a drop in baseline disease activity scores of ~30% and ~70% respectively. CONCLUSION: Our article reports the largest cohort published to date of new-onset IRD following SARS-CoV-2 infection or COVID-19 vaccines. Although causality cannot be ascertained, the spectrum of possible clinical manifestations is broad and includes IJD, PMR, CTD and vasculitis. BMJ Publishing Group 2023-06-16 /pmc/articles/PMC10276969/ /pubmed/37328292 http://dx.doi.org/10.1136/rmdopen-2023-003022 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Miscellaneous Ursini, Francesco Ruscitti, Piero Addimanda, Olga Foti, Rosario Raimondo, Vincenzo Murdaca, Giuseppe Caira, Virginia Pigatto, Erika Cuomo, Giovanna Lo Gullo, Alberto Cavazzana, Ilaria Campochiaro, Corrado Naclerio, Caterina De Angelis, Rossella Ciaffi, Jacopo Mancarella, Luana Brusi, Veronica Marchetti, Elena Motta, Francesca Visentini, Marcella Lorusso, Sebastiano De Santis, Maria De Luca, Giacomo Massaro, Laura Olivo, Domenico Pellegrini, Roberta Francioso, Francesca Luppino, Jessica Di Cola, Ilenia Foti, Roberta Varcasia, Giuseppe Caso, Francesco Reta, Massimo Dagna, Lorenzo Selmi, Carlo Iagnocco, Annamaria Giacomelli, Roberto Iannone, Florenzo Ferri, Clodoveo Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group |
title | Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group |
title_full | Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group |
title_fullStr | Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group |
title_full_unstemmed | Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group |
title_short | Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group |
title_sort | inflammatory rheumatic diseases with onset after sars-cov-2 infection or covid-19 vaccination: a report of 267 cases from the covid-19 and asd group |
topic | Miscellaneous |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10276969/ https://www.ncbi.nlm.nih.gov/pubmed/37328292 http://dx.doi.org/10.1136/rmdopen-2023-003022 |
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