Novel Anti-obesity Therapies and their Different Effects and Safety Profiles: A Critical Overview

Obesity has become an epidemic and a worldwide problem and its treatment is ever-evolving. Apart from diet and exercise, medication and surgery are other options. After disappointing side effects of various obesity drugs, new treatments showed promising results. This review discusses the following a...

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Autores principales: Telci Caklili, Ozge, Cesur, Mustafa, Mikhailidis, Dimitri P, Rizzo, Manfredi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277000/
https://www.ncbi.nlm.nih.gov/pubmed/37337548
http://dx.doi.org/10.2147/DMSO.S392684
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author Telci Caklili, Ozge
Cesur, Mustafa
Mikhailidis, Dimitri P
Rizzo, Manfredi
author_facet Telci Caklili, Ozge
Cesur, Mustafa
Mikhailidis, Dimitri P
Rizzo, Manfredi
author_sort Telci Caklili, Ozge
collection PubMed
description Obesity has become an epidemic and a worldwide problem and its treatment is ever-evolving. Apart from diet and exercise, medication and surgery are other options. After disappointing side effects of various obesity drugs, new treatments showed promising results. This review discusses the following anti-obesity drugs: liraglutide, semaglutide, tirzepatide, orlistat, as well as the phentermine/topiramate and bupropion/naltrexone combinations. These drugs have been approved by the Food and Drug Administration (FDA) for weight reduction except for tirzepatide which is still under evaluation. Efficacy and tolerable safety profiles of some of these drugs contribute to the management of obesity and reduce the complications associated with this chronic disease.
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spelling pubmed-102770002023-06-19 Novel Anti-obesity Therapies and their Different Effects and Safety Profiles: A Critical Overview Telci Caklili, Ozge Cesur, Mustafa Mikhailidis, Dimitri P Rizzo, Manfredi Diabetes Metab Syndr Obes Review Obesity has become an epidemic and a worldwide problem and its treatment is ever-evolving. Apart from diet and exercise, medication and surgery are other options. After disappointing side effects of various obesity drugs, new treatments showed promising results. This review discusses the following anti-obesity drugs: liraglutide, semaglutide, tirzepatide, orlistat, as well as the phentermine/topiramate and bupropion/naltrexone combinations. These drugs have been approved by the Food and Drug Administration (FDA) for weight reduction except for tirzepatide which is still under evaluation. Efficacy and tolerable safety profiles of some of these drugs contribute to the management of obesity and reduce the complications associated with this chronic disease. Dove 2023-06-14 /pmc/articles/PMC10277000/ /pubmed/37337548 http://dx.doi.org/10.2147/DMSO.S392684 Text en © 2023 Telci Caklili et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Telci Caklili, Ozge
Cesur, Mustafa
Mikhailidis, Dimitri P
Rizzo, Manfredi
Novel Anti-obesity Therapies and their Different Effects and Safety Profiles: A Critical Overview
title Novel Anti-obesity Therapies and their Different Effects and Safety Profiles: A Critical Overview
title_full Novel Anti-obesity Therapies and their Different Effects and Safety Profiles: A Critical Overview
title_fullStr Novel Anti-obesity Therapies and their Different Effects and Safety Profiles: A Critical Overview
title_full_unstemmed Novel Anti-obesity Therapies and their Different Effects and Safety Profiles: A Critical Overview
title_short Novel Anti-obesity Therapies and their Different Effects and Safety Profiles: A Critical Overview
title_sort novel anti-obesity therapies and their different effects and safety profiles: a critical overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277000/
https://www.ncbi.nlm.nih.gov/pubmed/37337548
http://dx.doi.org/10.2147/DMSO.S392684
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