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Prevalence and impact of exercise-induced laryngeal obstruction in asthma: a study protocol for a cross-sectional and longitudinal study

INTRODUCTION: Exercise-induced laryngeal obstruction (EILO) and exercise-induced asthma can cause troublesome respiratory symptoms that can be difficult to distinguish between. Further, there is now a growing appreciation that the two conditions may coexist, complicating the interpretation of sympto...

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Autores principales: Rogde, Åse Johnsen, Lehmann, Sverre, Halvorsen, Thomas, Clemm, Hege Havstad, Røksund, Ola Drange, Hufthammer, Karl Ove, Kvidaland, Haakon Kristian, Vollsæter, Maria, Andersen, Tiina Maarit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277068/
https://www.ncbi.nlm.nih.gov/pubmed/37328176
http://dx.doi.org/10.1136/bmjopen-2022-071159
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author Rogde, Åse Johnsen
Lehmann, Sverre
Halvorsen, Thomas
Clemm, Hege Havstad
Røksund, Ola Drange
Hufthammer, Karl Ove
Kvidaland, Haakon Kristian
Vollsæter, Maria
Andersen, Tiina Maarit
author_facet Rogde, Åse Johnsen
Lehmann, Sverre
Halvorsen, Thomas
Clemm, Hege Havstad
Røksund, Ola Drange
Hufthammer, Karl Ove
Kvidaland, Haakon Kristian
Vollsæter, Maria
Andersen, Tiina Maarit
author_sort Rogde, Åse Johnsen
collection PubMed
description INTRODUCTION: Exercise-induced laryngeal obstruction (EILO) and exercise-induced asthma can cause troublesome respiratory symptoms that can be difficult to distinguish between. Further, there is now a growing appreciation that the two conditions may coexist, complicating the interpretation of symptoms. The primary aim of this study is to investigate the prevalence of EILO in patients with asthma. Secondary aims include evaluation of EILO treatment effects and investigation of comorbid conditions other than EILO in patients with asthma. METHODS AND ANALYSIS: The study will be conducted at Haukeland University Hospital and Voss Hospital in Western Norway, and enrol 80–120 patients with asthma and a control group of 40 patients without asthma. Recruitment started in November 2020, and data sampling will continue until March 2024. Laryngeal function will be assessed at baseline and at a 1-year follow-up, using continuous laryngoscopy during high-intensity exercise (CLE). Immediately after the EILO diagnosis is verified, patients will be treated with standardised breathing advice guided by visual biofeedback from the laryngoscope video screen. The primary outcome will be the prevalence of EILO in patients with asthma and control participants. Secondary outcomes include changes in CLE scores, asthma-related quality of life, asthma control and number of the asthma exacerbations, as assessed between baseline and the 1-year follow-up. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the Regional Committee for Medical and Health Research Ethics, Western Norway, (ID number 97615). All participants will provide signed informed consent before enrolment. The results will be presented in international journals and conferences. TRIAL REGISTRATION NUMBER: NCT04593394.
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spelling pubmed-102770682023-06-19 Prevalence and impact of exercise-induced laryngeal obstruction in asthma: a study protocol for a cross-sectional and longitudinal study Rogde, Åse Johnsen Lehmann, Sverre Halvorsen, Thomas Clemm, Hege Havstad Røksund, Ola Drange Hufthammer, Karl Ove Kvidaland, Haakon Kristian Vollsæter, Maria Andersen, Tiina Maarit BMJ Open Respiratory Medicine INTRODUCTION: Exercise-induced laryngeal obstruction (EILO) and exercise-induced asthma can cause troublesome respiratory symptoms that can be difficult to distinguish between. Further, there is now a growing appreciation that the two conditions may coexist, complicating the interpretation of symptoms. The primary aim of this study is to investigate the prevalence of EILO in patients with asthma. Secondary aims include evaluation of EILO treatment effects and investigation of comorbid conditions other than EILO in patients with asthma. METHODS AND ANALYSIS: The study will be conducted at Haukeland University Hospital and Voss Hospital in Western Norway, and enrol 80–120 patients with asthma and a control group of 40 patients without asthma. Recruitment started in November 2020, and data sampling will continue until March 2024. Laryngeal function will be assessed at baseline and at a 1-year follow-up, using continuous laryngoscopy during high-intensity exercise (CLE). Immediately after the EILO diagnosis is verified, patients will be treated with standardised breathing advice guided by visual biofeedback from the laryngoscope video screen. The primary outcome will be the prevalence of EILO in patients with asthma and control participants. Secondary outcomes include changes in CLE scores, asthma-related quality of life, asthma control and number of the asthma exacerbations, as assessed between baseline and the 1-year follow-up. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the Regional Committee for Medical and Health Research Ethics, Western Norway, (ID number 97615). All participants will provide signed informed consent before enrolment. The results will be presented in international journals and conferences. TRIAL REGISTRATION NUMBER: NCT04593394. BMJ Publishing Group 2023-06-16 /pmc/articles/PMC10277068/ /pubmed/37328176 http://dx.doi.org/10.1136/bmjopen-2022-071159 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Respiratory Medicine
Rogde, Åse Johnsen
Lehmann, Sverre
Halvorsen, Thomas
Clemm, Hege Havstad
Røksund, Ola Drange
Hufthammer, Karl Ove
Kvidaland, Haakon Kristian
Vollsæter, Maria
Andersen, Tiina Maarit
Prevalence and impact of exercise-induced laryngeal obstruction in asthma: a study protocol for a cross-sectional and longitudinal study
title Prevalence and impact of exercise-induced laryngeal obstruction in asthma: a study protocol for a cross-sectional and longitudinal study
title_full Prevalence and impact of exercise-induced laryngeal obstruction in asthma: a study protocol for a cross-sectional and longitudinal study
title_fullStr Prevalence and impact of exercise-induced laryngeal obstruction in asthma: a study protocol for a cross-sectional and longitudinal study
title_full_unstemmed Prevalence and impact of exercise-induced laryngeal obstruction in asthma: a study protocol for a cross-sectional and longitudinal study
title_short Prevalence and impact of exercise-induced laryngeal obstruction in asthma: a study protocol for a cross-sectional and longitudinal study
title_sort prevalence and impact of exercise-induced laryngeal obstruction in asthma: a study protocol for a cross-sectional and longitudinal study
topic Respiratory Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277068/
https://www.ncbi.nlm.nih.gov/pubmed/37328176
http://dx.doi.org/10.1136/bmjopen-2022-071159
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