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Hematological Abnormalities in Cirrhosis: A Narrative Review

Liver cirrhosis remains a major public health issue. Liver fibrosis leading to cirrhosis is the terminal stage of various chronic liver diseases. Inflammatory cytokines are involved in the pathogenesis. Patients with cirrhosis often have hematological abnormalities, such as anemia and thrombocytopen...

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Detalles Bibliográficos
Autor principal: Lingas, Elvina C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277171/
https://www.ncbi.nlm.nih.gov/pubmed/37337504
http://dx.doi.org/10.7759/cureus.39239
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author Lingas, Elvina C
author_facet Lingas, Elvina C
author_sort Lingas, Elvina C
collection PubMed
description Liver cirrhosis remains a major public health issue. Liver fibrosis leading to cirrhosis is the terminal stage of various chronic liver diseases. Inflammatory cytokines are involved in the pathogenesis. Patients with cirrhosis often have hematological abnormalities, such as anemia and thrombocytopenia, which have multifactorial etiologies. Anemia in cirrhosis could be related to bleeding leading to iron deficiency anemia or other nutritional anemia such as vitamin B12 and folate deficiency. The pathophysiology of thrombocytopenia in liver cirrhosis has been postulated to range from splenic sequestration to bone marrow suppression from toxic agents, such as alcohol. It often complicates management due to the risk of bleeding with severely low platelets. This review aimed to highlight pathogenesis of liver cirrhosis, hematological abnormalities in liver cirrhosis, and their clinical significance.
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spelling pubmed-102771712023-06-19 Hematological Abnormalities in Cirrhosis: A Narrative Review Lingas, Elvina C Cureus Internal Medicine Liver cirrhosis remains a major public health issue. Liver fibrosis leading to cirrhosis is the terminal stage of various chronic liver diseases. Inflammatory cytokines are involved in the pathogenesis. Patients with cirrhosis often have hematological abnormalities, such as anemia and thrombocytopenia, which have multifactorial etiologies. Anemia in cirrhosis could be related to bleeding leading to iron deficiency anemia or other nutritional anemia such as vitamin B12 and folate deficiency. The pathophysiology of thrombocytopenia in liver cirrhosis has been postulated to range from splenic sequestration to bone marrow suppression from toxic agents, such as alcohol. It often complicates management due to the risk of bleeding with severely low platelets. This review aimed to highlight pathogenesis of liver cirrhosis, hematological abnormalities in liver cirrhosis, and their clinical significance. Cureus 2023-05-19 /pmc/articles/PMC10277171/ /pubmed/37337504 http://dx.doi.org/10.7759/cureus.39239 Text en Copyright © 2023, Lingas et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Lingas, Elvina C
Hematological Abnormalities in Cirrhosis: A Narrative Review
title Hematological Abnormalities in Cirrhosis: A Narrative Review
title_full Hematological Abnormalities in Cirrhosis: A Narrative Review
title_fullStr Hematological Abnormalities in Cirrhosis: A Narrative Review
title_full_unstemmed Hematological Abnormalities in Cirrhosis: A Narrative Review
title_short Hematological Abnormalities in Cirrhosis: A Narrative Review
title_sort hematological abnormalities in cirrhosis: a narrative review
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277171/
https://www.ncbi.nlm.nih.gov/pubmed/37337504
http://dx.doi.org/10.7759/cureus.39239
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