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Effects of hyaluronic acid and chondroitin sulfate on acute radiation proctitis in rats
BACKGROUND: This study was designed to investigate the prophylactic and therapeutic effects of hyaluronic acid and chondroitin sulfate combination (HA/CS) on a model of acute radiation proctitis. METHODS: Rats were divided into five groups: SHAM; irradiation (IR) + saline (1 mL for 5(th) and 10(th)...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kare Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277333/ https://www.ncbi.nlm.nih.gov/pubmed/37145048 http://dx.doi.org/10.14744/tjtes.2023.61582 |
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author | Yoldaş, Mehmet Yoldaş, Tayfun Solak, İlhami Çalışkan, Cemil Cin, Samed Doğanavşargil, Başak Sezak, Murat Alanyalı, Senem Yoldaş, Tuba Kuvvet |
author_facet | Yoldaş, Mehmet Yoldaş, Tayfun Solak, İlhami Çalışkan, Cemil Cin, Samed Doğanavşargil, Başak Sezak, Murat Alanyalı, Senem Yoldaş, Tuba Kuvvet |
author_sort | Yoldaş, Mehmet |
collection | PubMed |
description | BACKGROUND: This study was designed to investigate the prophylactic and therapeutic effects of hyaluronic acid and chondroitin sulfate combination (HA/CS) on a model of acute radiation proctitis. METHODS: Rats were divided into five groups: SHAM; irradiation (IR) + saline (1 mL for 5(th) and 10(th) day); IR + HA/CS (1 mL for 5(th) and 10(th) day). A single fraction of 17.5 Gy was delivered to each rat. HA/CS was administered rectally each day after irradiation. Each rat was observed daily for signs of proctitis. Irradiated rats were euthanized on days 5 and 10. The mucosal changes were evaluated macroscopically and pathologically. RESULTS: According to the clinical findings, five rats in the irradiation + saline group showed grade 3–4 symptoms on the 10(th) day. No significant difference in the macroscopic finding scores on the 5(th) day was observed between the irradiation + saline and irradiation + HA/CS groups. In the pathological examination, radiation-induced mucosal damage was the most prominent finding 10 days after irradiation in saline-treated rats. On the 10(th) day, the irradiation + HA/CS group showed mild inflammation and slight crypt changes, which corresponded to grade 1–2 pathological findings. CONCLUSION: We think that HA/CS used in radiation cystitis can be beneficial for radiation proctitis. |
format | Online Article Text |
id | pubmed-10277333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Kare Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-102773332023-06-20 Effects of hyaluronic acid and chondroitin sulfate on acute radiation proctitis in rats Yoldaş, Mehmet Yoldaş, Tayfun Solak, İlhami Çalışkan, Cemil Cin, Samed Doğanavşargil, Başak Sezak, Murat Alanyalı, Senem Yoldaş, Tuba Kuvvet Ulus Travma Acil Cerrahi Derg Experimental Study BACKGROUND: This study was designed to investigate the prophylactic and therapeutic effects of hyaluronic acid and chondroitin sulfate combination (HA/CS) on a model of acute radiation proctitis. METHODS: Rats were divided into five groups: SHAM; irradiation (IR) + saline (1 mL for 5(th) and 10(th) day); IR + HA/CS (1 mL for 5(th) and 10(th) day). A single fraction of 17.5 Gy was delivered to each rat. HA/CS was administered rectally each day after irradiation. Each rat was observed daily for signs of proctitis. Irradiated rats were euthanized on days 5 and 10. The mucosal changes were evaluated macroscopically and pathologically. RESULTS: According to the clinical findings, five rats in the irradiation + saline group showed grade 3–4 symptoms on the 10(th) day. No significant difference in the macroscopic finding scores on the 5(th) day was observed between the irradiation + saline and irradiation + HA/CS groups. In the pathological examination, radiation-induced mucosal damage was the most prominent finding 10 days after irradiation in saline-treated rats. On the 10(th) day, the irradiation + HA/CS group showed mild inflammation and slight crypt changes, which corresponded to grade 1–2 pathological findings. CONCLUSION: We think that HA/CS used in radiation cystitis can be beneficial for radiation proctitis. Kare Publishing 2023-05-02 /pmc/articles/PMC10277333/ /pubmed/37145048 http://dx.doi.org/10.14744/tjtes.2023.61582 Text en Copyright © 2023 Turkish Journal of Trauma and Emergency Surgery https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License |
spellingShingle | Experimental Study Yoldaş, Mehmet Yoldaş, Tayfun Solak, İlhami Çalışkan, Cemil Cin, Samed Doğanavşargil, Başak Sezak, Murat Alanyalı, Senem Yoldaş, Tuba Kuvvet Effects of hyaluronic acid and chondroitin sulfate on acute radiation proctitis in rats |
title | Effects of hyaluronic acid and chondroitin sulfate on acute radiation proctitis in rats |
title_full | Effects of hyaluronic acid and chondroitin sulfate on acute radiation proctitis in rats |
title_fullStr | Effects of hyaluronic acid and chondroitin sulfate on acute radiation proctitis in rats |
title_full_unstemmed | Effects of hyaluronic acid and chondroitin sulfate on acute radiation proctitis in rats |
title_short | Effects of hyaluronic acid and chondroitin sulfate on acute radiation proctitis in rats |
title_sort | effects of hyaluronic acid and chondroitin sulfate on acute radiation proctitis in rats |
topic | Experimental Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277333/ https://www.ncbi.nlm.nih.gov/pubmed/37145048 http://dx.doi.org/10.14744/tjtes.2023.61582 |
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