Budding uninhibited by benzimidazoles 1 promotes cell proliferation, invasion, and epithelial-mesenchymal transition via the Wnt/β-catenin signaling in glioblastoma

The pathogenesis and progression of GBM (glioblastoma), as one of the most frequently occurring malignancies of the central nervous system, are regulated by several genes. BUB1 (budding uninhibited by benzimidazoles 1) is a mitotic checkpoint that plays an important role in chromosome segregation as...

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Autores principales: Zhang, Jinshi, Wei, Wenjin, Zhong, Qinglin, Feng, Kaiming, Yang, Ruijin, Jiang, Qiuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277463/
https://www.ncbi.nlm.nih.gov/pubmed/37342577
http://dx.doi.org/10.1016/j.heliyon.2023.e16996
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author Zhang, Jinshi
Wei, Wenjin
Zhong, Qinglin
Feng, Kaiming
Yang, Ruijin
Jiang, Qiuhua
author_facet Zhang, Jinshi
Wei, Wenjin
Zhong, Qinglin
Feng, Kaiming
Yang, Ruijin
Jiang, Qiuhua
author_sort Zhang, Jinshi
collection PubMed
description The pathogenesis and progression of GBM (glioblastoma), as one of the most frequently occurring malignancies of the central nervous system, are regulated by several genes. BUB1 (budding uninhibited by benzimidazoles 1) is a mitotic checkpoint that plays an important role in chromosome segregation as well as in various tumors. However, its role in glioma is unknown. The current study discovered prominently elevated BUB1 in glioma and a significant relationship between BUB1 expression, a high World Health Organization grade, and a poor prognosis in glioma patients. Moreover, BUB1 triggered EMT (epithelial-mesenchymal transition) apart from promoting glioma cell proliferation, migration, and infiltration. Besides, BUB1 promoted EMT by activating the Wnt/β-catenin axis. As implied by our study, BUB1 probably has the potential as a target for GBM management.
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spelling pubmed-102774632023-06-20 Budding uninhibited by benzimidazoles 1 promotes cell proliferation, invasion, and epithelial-mesenchymal transition via the Wnt/β-catenin signaling in glioblastoma Zhang, Jinshi Wei, Wenjin Zhong, Qinglin Feng, Kaiming Yang, Ruijin Jiang, Qiuhua Heliyon Research Article The pathogenesis and progression of GBM (glioblastoma), as one of the most frequently occurring malignancies of the central nervous system, are regulated by several genes. BUB1 (budding uninhibited by benzimidazoles 1) is a mitotic checkpoint that plays an important role in chromosome segregation as well as in various tumors. However, its role in glioma is unknown. The current study discovered prominently elevated BUB1 in glioma and a significant relationship between BUB1 expression, a high World Health Organization grade, and a poor prognosis in glioma patients. Moreover, BUB1 triggered EMT (epithelial-mesenchymal transition) apart from promoting glioma cell proliferation, migration, and infiltration. Besides, BUB1 promoted EMT by activating the Wnt/β-catenin axis. As implied by our study, BUB1 probably has the potential as a target for GBM management. Elsevier 2023-06-12 /pmc/articles/PMC10277463/ /pubmed/37342577 http://dx.doi.org/10.1016/j.heliyon.2023.e16996 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Zhang, Jinshi
Wei, Wenjin
Zhong, Qinglin
Feng, Kaiming
Yang, Ruijin
Jiang, Qiuhua
Budding uninhibited by benzimidazoles 1 promotes cell proliferation, invasion, and epithelial-mesenchymal transition via the Wnt/β-catenin signaling in glioblastoma
title Budding uninhibited by benzimidazoles 1 promotes cell proliferation, invasion, and epithelial-mesenchymal transition via the Wnt/β-catenin signaling in glioblastoma
title_full Budding uninhibited by benzimidazoles 1 promotes cell proliferation, invasion, and epithelial-mesenchymal transition via the Wnt/β-catenin signaling in glioblastoma
title_fullStr Budding uninhibited by benzimidazoles 1 promotes cell proliferation, invasion, and epithelial-mesenchymal transition via the Wnt/β-catenin signaling in glioblastoma
title_full_unstemmed Budding uninhibited by benzimidazoles 1 promotes cell proliferation, invasion, and epithelial-mesenchymal transition via the Wnt/β-catenin signaling in glioblastoma
title_short Budding uninhibited by benzimidazoles 1 promotes cell proliferation, invasion, and epithelial-mesenchymal transition via the Wnt/β-catenin signaling in glioblastoma
title_sort budding uninhibited by benzimidazoles 1 promotes cell proliferation, invasion, and epithelial-mesenchymal transition via the wnt/β-catenin signaling in glioblastoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277463/
https://www.ncbi.nlm.nih.gov/pubmed/37342577
http://dx.doi.org/10.1016/j.heliyon.2023.e16996
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