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Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection
Herpes simplex virus 1 (HSV-1) is a widely distributed virus. HSV-1 is a growing public health concern due to the emergence of drug-resistant strains and the current lack of a clinically specific drug for treatment. In recent years, increasing attention has been paid to the development of peptide an...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277505/ https://www.ncbi.nlm.nih.gov/pubmed/37342565 http://dx.doi.org/10.3389/fmicb.2023.1201505 |
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author | Guo, Xiaomin An, Yanxing Tan, Wanmin Ma, Ling Wang, Mingyang Li, Juyan Li, Binghong Hou, Wei Wu, Li |
author_facet | Guo, Xiaomin An, Yanxing Tan, Wanmin Ma, Ling Wang, Mingyang Li, Juyan Li, Binghong Hou, Wei Wu, Li |
author_sort | Guo, Xiaomin |
collection | PubMed |
description | Herpes simplex virus 1 (HSV-1) is a widely distributed virus. HSV-1 is a growing public health concern due to the emergence of drug-resistant strains and the current lack of a clinically specific drug for treatment. In recent years, increasing attention has been paid to the development of peptide antivirals. Natural host-defense peptides which have uniquely evolved to protect the host have been reported to have antiviral properties. Cathelicidins are a family of multi-functional antimicrobial peptides found in almost all vertebrate species and play a vital role in the immune system. In this study, we demonstrated the anti-HSV-1 effect of an antiviral peptide named WL-1 derived from human cathelicidin. We found that WL-1 inhibited HSV-1 infection in epithelial and neuronal cells. Furthermore, the administration of WL-1 improved the survival rate and reduced viral load and inflammation during HSV-1 infection via ocular scarification. Moreover, facial nerve dysfunction, involving the abnormal blink reflex, nose position, and vibrissae movement, and pathological injury were prevented when HSV-1 ear inoculation-infected mice were treated with WL-1. Together, our findings demonstrate that WL-1 may be a potential novel antiviral agent against HSV-1 infection-induced facial palsy. |
format | Online Article Text |
id | pubmed-10277505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102775052023-06-20 Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection Guo, Xiaomin An, Yanxing Tan, Wanmin Ma, Ling Wang, Mingyang Li, Juyan Li, Binghong Hou, Wei Wu, Li Front Microbiol Microbiology Herpes simplex virus 1 (HSV-1) is a widely distributed virus. HSV-1 is a growing public health concern due to the emergence of drug-resistant strains and the current lack of a clinically specific drug for treatment. In recent years, increasing attention has been paid to the development of peptide antivirals. Natural host-defense peptides which have uniquely evolved to protect the host have been reported to have antiviral properties. Cathelicidins are a family of multi-functional antimicrobial peptides found in almost all vertebrate species and play a vital role in the immune system. In this study, we demonstrated the anti-HSV-1 effect of an antiviral peptide named WL-1 derived from human cathelicidin. We found that WL-1 inhibited HSV-1 infection in epithelial and neuronal cells. Furthermore, the administration of WL-1 improved the survival rate and reduced viral load and inflammation during HSV-1 infection via ocular scarification. Moreover, facial nerve dysfunction, involving the abnormal blink reflex, nose position, and vibrissae movement, and pathological injury were prevented when HSV-1 ear inoculation-infected mice were treated with WL-1. Together, our findings demonstrate that WL-1 may be a potential novel antiviral agent against HSV-1 infection-induced facial palsy. Frontiers Media S.A. 2023-06-05 /pmc/articles/PMC10277505/ /pubmed/37342565 http://dx.doi.org/10.3389/fmicb.2023.1201505 Text en Copyright © 2023 Guo, An, Tan, Ma, Wang, Li, Li, Hou and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Guo, Xiaomin An, Yanxing Tan, Wanmin Ma, Ling Wang, Mingyang Li, Juyan Li, Binghong Hou, Wei Wu, Li Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection |
title | Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection |
title_full | Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection |
title_fullStr | Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection |
title_full_unstemmed | Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection |
title_short | Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection |
title_sort | cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277505/ https://www.ncbi.nlm.nih.gov/pubmed/37342565 http://dx.doi.org/10.3389/fmicb.2023.1201505 |
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