A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer

BACKGROUND: Immune exclusion (IE) where tumors deter the infiltration of immune cells into the tumor microenvironment has emerged as a key mechanism underlying immunotherapy resistance. We recently reported a novel role of discoidin domain-containing receptor 1 (DDR1) in promoting IE in breast cance...

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Detalles Bibliográficos
Autores principales: Liu, Junquan, Chiang, Huai-Chin, Xiong, Wei, Laurent, Victor, Griffiths, Samuel C, Dülfer, Jasmin, Deng, Hui, Sun, Xiujie, Yin, Y Whitney, Li, Wenliang, Audoly, Laurent P, An, Zhiqiang, Schürpf, Thomas, Li, Rong, Zhang, Ningyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277525/
https://www.ncbi.nlm.nih.gov/pubmed/37328286
http://dx.doi.org/10.1136/jitc-2023-006720

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