Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study

BACKGROUND: Locally advanced/recurrent head and neck squamous cell carcinoma (HNSCC) is associated with significant morbidity and mortality. To target upregulated ErbB dimer expression in this cancer, we developed an autologous CD28-based chimeric antigen receptor T-cell (CAR-T) approach named T4 im...

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Detalles Bibliográficos
Autores principales: Papa, Sophie, Adami, Antonella, Metoudi, Michael, Beatson, Richard, George, Molly Sarah, Achkova, Daniela, Williams, Evangelia, Arif, Sefina, Reid, Fiona, Elstad, Maria, Beckley-Hoelscher, Nicholas, Douri, Abdel, Delord, Marc, Lyne, Mike, Shivapatham, Dharshene, Fisher, Christopher, Hope, Andrew, Gooljar, Sakina, Mitra, Arindam, Gomm, Linda, Morton, Cienne, Henley-Smith, Rhonda, Thavaraj, Selvam, Santambrogio, Alice, Andoniadou, Cynthia, Allen, Sarah, Gibson, Victoria, Cook, Gary J R, Parente-Pereira, Ana C, Davies, David M, Farzaneh, Farzin, Schurich, Anna, Guerrero-Urbano, Teresa, Jeannon, Jean-Pierre, Spicer, James, Maher, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277526/
https://www.ncbi.nlm.nih.gov/pubmed/37321663
http://dx.doi.org/10.1136/jitc-2023-007162

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