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2,5-dimethylcelecoxib alleviated NK and T-cell exhaustion in hepatocellular carcinoma via the gastrointestinal microbiota-AMPK-mTOR axis

BACKGROUND: 2,5-dimethylcelecoxib (DMC), a derivative of celecoxib, is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1). Our previous studies have demonstrated that DMC inhibits the expression of programmed death-ligand 1 on hepatocellular carcinoma (HCC) cells to prevent tumor progre...

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Detalles Bibliográficos
Autores principales:	Pan, Banglun, Chen, Zhanfei, Zhang, Xiaoxia, Wang, Zengbin, Yao, Yuxin, Wu, Xiaoxuan, Qiu, Jiacheng, Lin, Hua, Yu, Liumin, Tu, Haijian, Tang, Nanhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277542/ https://www.ncbi.nlm.nih.gov/pubmed/37316264 http://dx.doi.org/10.1136/jitc-2023-006817

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