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Case report: High-resolution, intra-operative µDoppler-imaging of spinal cord hemangioblastoma

Surgical resection of spinal cord hemangioblastomas remains a challenging endeavor: the neurosurgeon’s aim to reach total tumor resections directly endangers their aim to minimize post-operative neurological deficits. The currently available tools to guide the neurosurgeon’s intra-operative decision...

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Autores principales: Soloukey, Sadaf, Verhoef, Luuk, Generowicz, Bastian S., De Zeeuw, Chris I., Koekkoek, Sebastiaan K. E., Vincent, Arnaud J. P. E., Dirven, Clemens M. F., Harhangi, Biswadjiet S., Kruizinga, Pieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277559/
https://www.ncbi.nlm.nih.gov/pubmed/37342792
http://dx.doi.org/10.3389/fsurg.2023.1153605
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author Soloukey, Sadaf
Verhoef, Luuk
Generowicz, Bastian S.
De Zeeuw, Chris I.
Koekkoek, Sebastiaan K. E.
Vincent, Arnaud J. P. E.
Dirven, Clemens M. F.
Harhangi, Biswadjiet S.
Kruizinga, Pieter
author_facet Soloukey, Sadaf
Verhoef, Luuk
Generowicz, Bastian S.
De Zeeuw, Chris I.
Koekkoek, Sebastiaan K. E.
Vincent, Arnaud J. P. E.
Dirven, Clemens M. F.
Harhangi, Biswadjiet S.
Kruizinga, Pieter
author_sort Soloukey, Sadaf
collection PubMed
description Surgical resection of spinal cord hemangioblastomas remains a challenging endeavor: the neurosurgeon’s aim to reach total tumor resections directly endangers their aim to minimize post-operative neurological deficits. The currently available tools to guide the neurosurgeon’s intra-operative decision-making consist mostly of pre-operative imaging techniques such as MRI or MRA, which cannot cater to intra-operative changes in field of view. For a while now, spinal cord surgeons have adopted ultrasound and its submodalities such as Doppler and CEUS as intra-operative techniques, given their many benefits such as real-time feedback, mobility and ease of use. However, for highly vascularized lesions such as hemangioblastomas, which contain up to capillary-level microvasculature, having access to higher-resolution intra-operative vascular imaging could potentially be highly beneficial. µDoppler-imaging is a new imaging modality especially fit for high-resolution hemodynamic imaging. Over the last decade, µDoppler-imaging has emerged as a high-resolution, contrast-free sonography-based technique which relies on High-Frame-Rate (HFR)-ultrasound and subsequent Doppler processing. In contrast to conventional millimeter-scale (Doppler) ultrasound, the µDoppler technique has a higher sensitivity to detect slow flow in the entire field-of-view which allows for unprecedented visualization of blood flow down to sub-millimeter resolution. In contrast to CEUS, µDoppler is able to image high-resolution details continuously, without being contrast bolus-dependent. Previously, our team has demonstrated the use of this technique in the context of functional brain mapping during awake brain tumor resections and surgical resections of cerebral arteriovenous malformations (AVM). However, the application of µDoppler-imaging in the context of the spinal cord has remained restricted to a handful of mostly pre-clinical animal studies. Here we describe the first application of µDoppler-imaging in the case of a patient with two thoracic spinal hemangioblastomas. We demonstrate how µDoppler is able to identify intra-operatively and with high-resolution, hemodynamic features of the lesion. In contrast to pre-operative MRA, µDoppler could identify intralesional vascular details, in real-time during the surgical procedure. Additionally, we show highly detailed post-resection images of physiological human spinal cord anatomy. Finally, we discuss the necessary future steps to push µDoppler to reach actual clinical maturity.
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spelling pubmed-102775592023-06-20 Case report: High-resolution, intra-operative µDoppler-imaging of spinal cord hemangioblastoma Soloukey, Sadaf Verhoef, Luuk Generowicz, Bastian S. De Zeeuw, Chris I. Koekkoek, Sebastiaan K. E. Vincent, Arnaud J. P. E. Dirven, Clemens M. F. Harhangi, Biswadjiet S. Kruizinga, Pieter Front Surg Surgery Surgical resection of spinal cord hemangioblastomas remains a challenging endeavor: the neurosurgeon’s aim to reach total tumor resections directly endangers their aim to minimize post-operative neurological deficits. The currently available tools to guide the neurosurgeon’s intra-operative decision-making consist mostly of pre-operative imaging techniques such as MRI or MRA, which cannot cater to intra-operative changes in field of view. For a while now, spinal cord surgeons have adopted ultrasound and its submodalities such as Doppler and CEUS as intra-operative techniques, given their many benefits such as real-time feedback, mobility and ease of use. However, for highly vascularized lesions such as hemangioblastomas, which contain up to capillary-level microvasculature, having access to higher-resolution intra-operative vascular imaging could potentially be highly beneficial. µDoppler-imaging is a new imaging modality especially fit for high-resolution hemodynamic imaging. Over the last decade, µDoppler-imaging has emerged as a high-resolution, contrast-free sonography-based technique which relies on High-Frame-Rate (HFR)-ultrasound and subsequent Doppler processing. In contrast to conventional millimeter-scale (Doppler) ultrasound, the µDoppler technique has a higher sensitivity to detect slow flow in the entire field-of-view which allows for unprecedented visualization of blood flow down to sub-millimeter resolution. In contrast to CEUS, µDoppler is able to image high-resolution details continuously, without being contrast bolus-dependent. Previously, our team has demonstrated the use of this technique in the context of functional brain mapping during awake brain tumor resections and surgical resections of cerebral arteriovenous malformations (AVM). However, the application of µDoppler-imaging in the context of the spinal cord has remained restricted to a handful of mostly pre-clinical animal studies. Here we describe the first application of µDoppler-imaging in the case of a patient with two thoracic spinal hemangioblastomas. We demonstrate how µDoppler is able to identify intra-operatively and with high-resolution, hemodynamic features of the lesion. In contrast to pre-operative MRA, µDoppler could identify intralesional vascular details, in real-time during the surgical procedure. Additionally, we show highly detailed post-resection images of physiological human spinal cord anatomy. Finally, we discuss the necessary future steps to push µDoppler to reach actual clinical maturity. Frontiers Media S.A. 2023-06-05 /pmc/articles/PMC10277559/ /pubmed/37342792 http://dx.doi.org/10.3389/fsurg.2023.1153605 Text en © 2023 Soloukey, Verhoef, Generowicz, De Zeeuw, Koekkoek, Vincent, Dirven, Harhangi and Kruizinga. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Soloukey, Sadaf
Verhoef, Luuk
Generowicz, Bastian S.
De Zeeuw, Chris I.
Koekkoek, Sebastiaan K. E.
Vincent, Arnaud J. P. E.
Dirven, Clemens M. F.
Harhangi, Biswadjiet S.
Kruizinga, Pieter
Case report: High-resolution, intra-operative µDoppler-imaging of spinal cord hemangioblastoma
title Case report: High-resolution, intra-operative µDoppler-imaging of spinal cord hemangioblastoma
title_full Case report: High-resolution, intra-operative µDoppler-imaging of spinal cord hemangioblastoma
title_fullStr Case report: High-resolution, intra-operative µDoppler-imaging of spinal cord hemangioblastoma
title_full_unstemmed Case report: High-resolution, intra-operative µDoppler-imaging of spinal cord hemangioblastoma
title_short Case report: High-resolution, intra-operative µDoppler-imaging of spinal cord hemangioblastoma
title_sort case report: high-resolution, intra-operative µdoppler-imaging of spinal cord hemangioblastoma
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277559/
https://www.ncbi.nlm.nih.gov/pubmed/37342792
http://dx.doi.org/10.3389/fsurg.2023.1153605
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