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Mitochondria spatially and temporally modulate VSMC phenotypes via interacting with cytoskeleton in cardiovascular diseases

Cardiovascular diseases caused by atherosclerosis (AS) seriously endanger human health, which is closely related to vascular smooth muscle cell (VSMC) phenotypes. VSMC phenotypic transformation is marked by the alteration of phenotypic marker expression and cellular behaviour. Intriguingly, the mito...

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Autores principales: Li, Jingwen, Li, Xinyue, Song, Sijie, Sun, Zhengwen, Li, Yuanzhu, Yang, Long, Xie, Zhenhong, Cai, Yikui, Zhao, Yinping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277590/
https://www.ncbi.nlm.nih.gov/pubmed/37321061
http://dx.doi.org/10.1016/j.redox.2023.102778
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author Li, Jingwen
Li, Xinyue
Song, Sijie
Sun, Zhengwen
Li, Yuanzhu
Yang, Long
Xie, Zhenhong
Cai, Yikui
Zhao, Yinping
author_facet Li, Jingwen
Li, Xinyue
Song, Sijie
Sun, Zhengwen
Li, Yuanzhu
Yang, Long
Xie, Zhenhong
Cai, Yikui
Zhao, Yinping
author_sort Li, Jingwen
collection PubMed
description Cardiovascular diseases caused by atherosclerosis (AS) seriously endanger human health, which is closely related to vascular smooth muscle cell (VSMC) phenotypes. VSMC phenotypic transformation is marked by the alteration of phenotypic marker expression and cellular behaviour. Intriguingly, the mitochondrial metabolism and dynamics altered during VSMC phenotypic transformation. Firstly, this review combs VSMC mitochondrial metabolism in three aspects: mitochondrial ROS generation, mutated mitochondrial DNA (mtDNA) and calcium metabolism respectively. Secondly, we summarized the role of mitochondrial dynamics in regulating VSMC phenotypes. We further emphasized the association between mitochondria and cytoskelton via presenting cytoskeletal support during mitochondrial dynamics process, and discussed its impact on their respective dynamics. Finally, considering that both mitochondria and cytoskeleton are mechano-sensitive organelles, we demonstrated their direct and indirect interaction under extracellular mechanical stimuli through several mechano-sensitive signaling pathways. We additionally discussed related researches in other cell types in order to inspire deeper thinking and reasonable speculation of potential regulatory mechanism in VSMC phenotypic transformation.
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spelling pubmed-102775902023-06-20 Mitochondria spatially and temporally modulate VSMC phenotypes via interacting with cytoskeleton in cardiovascular diseases Li, Jingwen Li, Xinyue Song, Sijie Sun, Zhengwen Li, Yuanzhu Yang, Long Xie, Zhenhong Cai, Yikui Zhao, Yinping Redox Biol Review Article Cardiovascular diseases caused by atherosclerosis (AS) seriously endanger human health, which is closely related to vascular smooth muscle cell (VSMC) phenotypes. VSMC phenotypic transformation is marked by the alteration of phenotypic marker expression and cellular behaviour. Intriguingly, the mitochondrial metabolism and dynamics altered during VSMC phenotypic transformation. Firstly, this review combs VSMC mitochondrial metabolism in three aspects: mitochondrial ROS generation, mutated mitochondrial DNA (mtDNA) and calcium metabolism respectively. Secondly, we summarized the role of mitochondrial dynamics in regulating VSMC phenotypes. We further emphasized the association between mitochondria and cytoskelton via presenting cytoskeletal support during mitochondrial dynamics process, and discussed its impact on their respective dynamics. Finally, considering that both mitochondria and cytoskeleton are mechano-sensitive organelles, we demonstrated their direct and indirect interaction under extracellular mechanical stimuli through several mechano-sensitive signaling pathways. We additionally discussed related researches in other cell types in order to inspire deeper thinking and reasonable speculation of potential regulatory mechanism in VSMC phenotypic transformation. Elsevier 2023-06-07 /pmc/articles/PMC10277590/ /pubmed/37321061 http://dx.doi.org/10.1016/j.redox.2023.102778 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Li, Jingwen
Li, Xinyue
Song, Sijie
Sun, Zhengwen
Li, Yuanzhu
Yang, Long
Xie, Zhenhong
Cai, Yikui
Zhao, Yinping
Mitochondria spatially and temporally modulate VSMC phenotypes via interacting with cytoskeleton in cardiovascular diseases
title Mitochondria spatially and temporally modulate VSMC phenotypes via interacting with cytoskeleton in cardiovascular diseases
title_full Mitochondria spatially and temporally modulate VSMC phenotypes via interacting with cytoskeleton in cardiovascular diseases
title_fullStr Mitochondria spatially and temporally modulate VSMC phenotypes via interacting with cytoskeleton in cardiovascular diseases
title_full_unstemmed Mitochondria spatially and temporally modulate VSMC phenotypes via interacting with cytoskeleton in cardiovascular diseases
title_short Mitochondria spatially and temporally modulate VSMC phenotypes via interacting with cytoskeleton in cardiovascular diseases
title_sort mitochondria spatially and temporally modulate vsmc phenotypes via interacting with cytoskeleton in cardiovascular diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277590/
https://www.ncbi.nlm.nih.gov/pubmed/37321061
http://dx.doi.org/10.1016/j.redox.2023.102778
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