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Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis
BACKGROUND: The prognosis of several malignancies has been influenced by the systemic immune-inflammation index (SII); however, its association with the prognostic outcome of ovarian cancer (OC) remains controversial. The present meta-analysis focused on the systemic and comprehensive identification...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277625/ https://www.ncbi.nlm.nih.gov/pubmed/37342198 http://dx.doi.org/10.3389/fonc.2023.1193962 |
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author | Mao, Huaying Yang, Fan |
author_facet | Mao, Huaying Yang, Fan |
author_sort | Mao, Huaying |
collection | PubMed |
description | BACKGROUND: The prognosis of several malignancies has been influenced by the systemic immune-inflammation index (SII); however, its association with the prognostic outcome of ovarian cancer (OC) remains controversial. The present meta-analysis focused on the systemic and comprehensive identification of the role of SII in predicting OC prognosis. METHODS: We searched the Web of Science, PubMed, Cochrane Library, Embase, and China National Knowledge Infrastructure (CNKI) from inception until March 6, 2023. To predict the prognostic value of SII for overall survival (OS) and progression-free survival (PFS) in patients with OC, we calculated pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). RESULTS: The meta-analysis included six studies involving 1546 patients. The combined results showed that a high SII was significantly associated with poor OS (HR=2.70, 95% CI=1.98–3.67, p<0.001) and poor PFS (HR=2.71, 95% CI=1.78–4.12, p<0.001) in OC patients. These results were confirmed using subgroup and sensitivity analyses. CONCLUSION: Our results concluded that a high SII significantly predicted poor OS and PFS in patients with OC. Therefore, it can be speculated that the SII may have an independent effect on the prognosis of OC. |
format | Online Article Text |
id | pubmed-10277625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102776252023-06-20 Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis Mao, Huaying Yang, Fan Front Oncol Oncology BACKGROUND: The prognosis of several malignancies has been influenced by the systemic immune-inflammation index (SII); however, its association with the prognostic outcome of ovarian cancer (OC) remains controversial. The present meta-analysis focused on the systemic and comprehensive identification of the role of SII in predicting OC prognosis. METHODS: We searched the Web of Science, PubMed, Cochrane Library, Embase, and China National Knowledge Infrastructure (CNKI) from inception until March 6, 2023. To predict the prognostic value of SII for overall survival (OS) and progression-free survival (PFS) in patients with OC, we calculated pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). RESULTS: The meta-analysis included six studies involving 1546 patients. The combined results showed that a high SII was significantly associated with poor OS (HR=2.70, 95% CI=1.98–3.67, p<0.001) and poor PFS (HR=2.71, 95% CI=1.78–4.12, p<0.001) in OC patients. These results were confirmed using subgroup and sensitivity analyses. CONCLUSION: Our results concluded that a high SII significantly predicted poor OS and PFS in patients with OC. Therefore, it can be speculated that the SII may have an independent effect on the prognosis of OC. Frontiers Media S.A. 2023-06-05 /pmc/articles/PMC10277625/ /pubmed/37342198 http://dx.doi.org/10.3389/fonc.2023.1193962 Text en Copyright © 2023 Mao and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Mao, Huaying Yang, Fan Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis |
title | Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis |
title_full | Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis |
title_fullStr | Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis |
title_full_unstemmed | Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis |
title_short | Prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis |
title_sort | prognostic significance of systemic immune-inflammation index in patients with ovarian cancer: a meta-analysis |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277625/ https://www.ncbi.nlm.nih.gov/pubmed/37342198 http://dx.doi.org/10.3389/fonc.2023.1193962 |
work_keys_str_mv | AT maohuaying prognosticsignificanceofsystemicimmuneinflammationindexinpatientswithovariancancerametaanalysis AT yangfan prognosticsignificanceofsystemicimmuneinflammationindexinpatientswithovariancancerametaanalysis |