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Association of all-cause mortality with sugar intake from different sources in the prospective cohort of UK Biobank participants

The present study elucidates the association of intrinsic sugars and free sugars (FS) from all relevant sources with all-cause mortality in the prospective UK Biobank cohort. Sugar intake was assessed in 186 811 UK Biobank participants who completed at least one web-based 24-h dietary recall (Oxford...

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Autores principales: Kaiser, Anna, Schaefer, Sylva M., Behrendt, Inken, Eichner, Gerrit, Fasshauer, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277665/
https://www.ncbi.nlm.nih.gov/pubmed/36204988
http://dx.doi.org/10.1017/S0007114522003233
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author Kaiser, Anna
Schaefer, Sylva M.
Behrendt, Inken
Eichner, Gerrit
Fasshauer, Mathias
author_facet Kaiser, Anna
Schaefer, Sylva M.
Behrendt, Inken
Eichner, Gerrit
Fasshauer, Mathias
author_sort Kaiser, Anna
collection PubMed
description The present study elucidates the association of intrinsic sugars and free sugars (FS) from all relevant sources with all-cause mortality in the prospective UK Biobank cohort. Sugar intake was assessed in 186 811 UK Biobank participants who completed at least one web-based 24-h dietary recall (Oxford WebQ). Cox proportional hazard regression models for all-cause mortality were used with sugar intake from different sources included as penalised cubic splines to allow non-linear predictor effects. Over a mean follow-up of 12·3 years, 8576 (4·6 %) deaths occurred. FS but not intrinsic sugars were significantly and dose-dependently associated with hazard ratio (HR) for all-cause mortality. The association with all-cause mortality was significant and dose dependent for FS in beverages, but not in solids with the mean (CI) HR at 50 g/d v. 0 g/d consumption at 1·10, 95 % CI (1·07, 1·14) and 1·01, 95 % CI (0·98, 1·03), respectively. Within the beverages subcategories, a significant dose-dependent association with mortality was detected for FS in soda/fruit drinks and milk-based drinks whereas this relation was NS for FS in pure juice and tea/coffee. FS in four different subtypes of solids, i.e. treats, cereals, toppings and sauces, were not positively associated with all-cause mortality. Major findings were robust in sensitivity analyses. In conclusion, only some FS sources were associated with all-cause mortality. Interventions targeting FS subtypes might be most effective concerning mortality if focused on the reduction of soda/fruit drinks and milk-based sugary drinks; however, the present results need to be confirmed by independent studies.
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spelling pubmed-102776652023-06-20 Association of all-cause mortality with sugar intake from different sources in the prospective cohort of UK Biobank participants Kaiser, Anna Schaefer, Sylva M. Behrendt, Inken Eichner, Gerrit Fasshauer, Mathias Br J Nutr Research Article The present study elucidates the association of intrinsic sugars and free sugars (FS) from all relevant sources with all-cause mortality in the prospective UK Biobank cohort. Sugar intake was assessed in 186 811 UK Biobank participants who completed at least one web-based 24-h dietary recall (Oxford WebQ). Cox proportional hazard regression models for all-cause mortality were used with sugar intake from different sources included as penalised cubic splines to allow non-linear predictor effects. Over a mean follow-up of 12·3 years, 8576 (4·6 %) deaths occurred. FS but not intrinsic sugars were significantly and dose-dependently associated with hazard ratio (HR) for all-cause mortality. The association with all-cause mortality was significant and dose dependent for FS in beverages, but not in solids with the mean (CI) HR at 50 g/d v. 0 g/d consumption at 1·10, 95 % CI (1·07, 1·14) and 1·01, 95 % CI (0·98, 1·03), respectively. Within the beverages subcategories, a significant dose-dependent association with mortality was detected for FS in soda/fruit drinks and milk-based drinks whereas this relation was NS for FS in pure juice and tea/coffee. FS in four different subtypes of solids, i.e. treats, cereals, toppings and sauces, were not positively associated with all-cause mortality. Major findings were robust in sensitivity analyses. In conclusion, only some FS sources were associated with all-cause mortality. Interventions targeting FS subtypes might be most effective concerning mortality if focused on the reduction of soda/fruit drinks and milk-based sugary drinks; however, the present results need to be confirmed by independent studies. Cambridge University Press 2023-07-28 2022-10-07 /pmc/articles/PMC10277665/ /pubmed/36204988 http://dx.doi.org/10.1017/S0007114522003233 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Research Article
Kaiser, Anna
Schaefer, Sylva M.
Behrendt, Inken
Eichner, Gerrit
Fasshauer, Mathias
Association of all-cause mortality with sugar intake from different sources in the prospective cohort of UK Biobank participants
title Association of all-cause mortality with sugar intake from different sources in the prospective cohort of UK Biobank participants
title_full Association of all-cause mortality with sugar intake from different sources in the prospective cohort of UK Biobank participants
title_fullStr Association of all-cause mortality with sugar intake from different sources in the prospective cohort of UK Biobank participants
title_full_unstemmed Association of all-cause mortality with sugar intake from different sources in the prospective cohort of UK Biobank participants
title_short Association of all-cause mortality with sugar intake from different sources in the prospective cohort of UK Biobank participants
title_sort association of all-cause mortality with sugar intake from different sources in the prospective cohort of uk biobank participants
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277665/
https://www.ncbi.nlm.nih.gov/pubmed/36204988
http://dx.doi.org/10.1017/S0007114522003233
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