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MEF2C/p300-mediated epigenetic remodeling promotes the maturation of induced cardiomyocytes

Cardiac transcription factors (TFs) directly reprogram fibroblasts into induced cardiomyocytes (iCMs), where MEF2C acts as a pioneer factor with GATA4 and TBX5 (GT). However, the generation of functional and mature iCMs is inefficient, and the molecular mechanisms underlying this process remain larg...

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Detalles Bibliográficos
Autores principales:	Kojima, Hidenori, Sadahiro, Taketaro, Muraoka, Naoto, Yamakawa, Hiroyuki, Hashimoto, Hisayuki, Ishii, Ryota, Gosho, Masahiko, Abe, Yuto, Yamada, Yu, Nakano, Koji, Honda, Seiichiro, Fujita, Ryo, Akiyama, Tatsuya, Sunagawa, Yoichi, Morimoto, Tatsuya, Tsukahara, Toshifumi, Hirai, Hiroyuki, Fukuda, Keiichi, Ieda, Masaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277823/ https://www.ncbi.nlm.nih.gov/pubmed/37315521 http://dx.doi.org/10.1016/j.stemcr.2023.05.001

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