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Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks
Injectable and in situ photocurable biomaterials are receiving a lot of attention due to their ease of application via syringe or dedicated applicator and ability to be used in laparoscopic and robotic minimally invasive procedures. The aim of this work was to synthesize photocurable ester-urethane...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277904/ https://www.ncbi.nlm.nih.gov/pubmed/37342811 http://dx.doi.org/10.1039/d3ra02157b |
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author | Niedźwiedź, Malwina J. Ignaczak, Wojciech Sobolewski, Peter Goszczyńska, Agata Demirci, Gokhan El Fray, Miroslawa |
author_facet | Niedźwiedź, Malwina J. Ignaczak, Wojciech Sobolewski, Peter Goszczyńska, Agata Demirci, Gokhan El Fray, Miroslawa |
author_sort | Niedźwiedź, Malwina J. |
collection | PubMed |
description | Injectable and in situ photocurable biomaterials are receiving a lot of attention due to their ease of application via syringe or dedicated applicator and ability to be used in laparoscopic and robotic minimally invasive procedures. The aim of this work was to synthesize photocurable ester-urethane macromonomers using a heterometallic magnesium-titanium catalyst, magnesium-titanium(iv) butoxide for elastomeric polymer networks. The progress of the two-step synthesis of macromonomers was monitored using infrared spectroscopy. The chemical structure and molecular weight of the obtained macromonomers were characterized using nuclear magnetic resonance spectroscopy and gel permeation chromatography. The dynamic viscosity of the obtained macromonomers was evaluated by a rheometer. Next, the photocuring process was studied under both air and argon atmospheres. Both the thermal and dynamic mechanical thermal properties of the photocured soft and elastomeric networks were investigated. Finally, in vitro cytotoxicity screening of polymer networks based on ISO10993-5 revealed high cell viability (over 77%) regardless of curing atmosphere. Overall, our results indicate that this heterometallic magnesium-titanium butoxide catalyst can be an attractive alternative to commonly used homometallic catalysts for the synthesis of injectable and photocurable materials for medical applications. |
format | Online Article Text |
id | pubmed-10277904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-102779042023-06-20 Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks Niedźwiedź, Malwina J. Ignaczak, Wojciech Sobolewski, Peter Goszczyńska, Agata Demirci, Gokhan El Fray, Miroslawa RSC Adv Chemistry Injectable and in situ photocurable biomaterials are receiving a lot of attention due to their ease of application via syringe or dedicated applicator and ability to be used in laparoscopic and robotic minimally invasive procedures. The aim of this work was to synthesize photocurable ester-urethane macromonomers using a heterometallic magnesium-titanium catalyst, magnesium-titanium(iv) butoxide for elastomeric polymer networks. The progress of the two-step synthesis of macromonomers was monitored using infrared spectroscopy. The chemical structure and molecular weight of the obtained macromonomers were characterized using nuclear magnetic resonance spectroscopy and gel permeation chromatography. The dynamic viscosity of the obtained macromonomers was evaluated by a rheometer. Next, the photocuring process was studied under both air and argon atmospheres. Both the thermal and dynamic mechanical thermal properties of the photocured soft and elastomeric networks were investigated. Finally, in vitro cytotoxicity screening of polymer networks based on ISO10993-5 revealed high cell viability (over 77%) regardless of curing atmosphere. Overall, our results indicate that this heterometallic magnesium-titanium butoxide catalyst can be an attractive alternative to commonly used homometallic catalysts for the synthesis of injectable and photocurable materials for medical applications. The Royal Society of Chemistry 2023-06-19 /pmc/articles/PMC10277904/ /pubmed/37342811 http://dx.doi.org/10.1039/d3ra02157b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Niedźwiedź, Malwina J. Ignaczak, Wojciech Sobolewski, Peter Goszczyńska, Agata Demirci, Gokhan El Fray, Miroslawa Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks |
title | Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks |
title_full | Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks |
title_fullStr | Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks |
title_full_unstemmed | Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks |
title_short | Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks |
title_sort | injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277904/ https://www.ncbi.nlm.nih.gov/pubmed/37342811 http://dx.doi.org/10.1039/d3ra02157b |
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