Cargando…

Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks

Injectable and in situ photocurable biomaterials are receiving a lot of attention due to their ease of application via syringe or dedicated applicator and ability to be used in laparoscopic and robotic minimally invasive procedures. The aim of this work was to synthesize photocurable ester-urethane...

Descripción completa

Detalles Bibliográficos
Autores principales: Niedźwiedź, Malwina J., Ignaczak, Wojciech, Sobolewski, Peter, Goszczyńska, Agata, Demirci, Gokhan, El Fray, Miroslawa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277904/
https://www.ncbi.nlm.nih.gov/pubmed/37342811
http://dx.doi.org/10.1039/d3ra02157b
_version_ 1785060382305419264
author Niedźwiedź, Malwina J.
Ignaczak, Wojciech
Sobolewski, Peter
Goszczyńska, Agata
Demirci, Gokhan
El Fray, Miroslawa
author_facet Niedźwiedź, Malwina J.
Ignaczak, Wojciech
Sobolewski, Peter
Goszczyńska, Agata
Demirci, Gokhan
El Fray, Miroslawa
author_sort Niedźwiedź, Malwina J.
collection PubMed
description Injectable and in situ photocurable biomaterials are receiving a lot of attention due to their ease of application via syringe or dedicated applicator and ability to be used in laparoscopic and robotic minimally invasive procedures. The aim of this work was to synthesize photocurable ester-urethane macromonomers using a heterometallic magnesium-titanium catalyst, magnesium-titanium(iv) butoxide for elastomeric polymer networks. The progress of the two-step synthesis of macromonomers was monitored using infrared spectroscopy. The chemical structure and molecular weight of the obtained macromonomers were characterized using nuclear magnetic resonance spectroscopy and gel permeation chromatography. The dynamic viscosity of the obtained macromonomers was evaluated by a rheometer. Next, the photocuring process was studied under both air and argon atmospheres. Both the thermal and dynamic mechanical thermal properties of the photocured soft and elastomeric networks were investigated. Finally, in vitro cytotoxicity screening of polymer networks based on ISO10993-5 revealed high cell viability (over 77%) regardless of curing atmosphere. Overall, our results indicate that this heterometallic magnesium-titanium butoxide catalyst can be an attractive alternative to commonly used homometallic catalysts for the synthesis of injectable and photocurable materials for medical applications.
format Online
Article
Text
id pubmed-10277904
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-102779042023-06-20 Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks Niedźwiedź, Malwina J. Ignaczak, Wojciech Sobolewski, Peter Goszczyńska, Agata Demirci, Gokhan El Fray, Miroslawa RSC Adv Chemistry Injectable and in situ photocurable biomaterials are receiving a lot of attention due to their ease of application via syringe or dedicated applicator and ability to be used in laparoscopic and robotic minimally invasive procedures. The aim of this work was to synthesize photocurable ester-urethane macromonomers using a heterometallic magnesium-titanium catalyst, magnesium-titanium(iv) butoxide for elastomeric polymer networks. The progress of the two-step synthesis of macromonomers was monitored using infrared spectroscopy. The chemical structure and molecular weight of the obtained macromonomers were characterized using nuclear magnetic resonance spectroscopy and gel permeation chromatography. The dynamic viscosity of the obtained macromonomers was evaluated by a rheometer. Next, the photocuring process was studied under both air and argon atmospheres. Both the thermal and dynamic mechanical thermal properties of the photocured soft and elastomeric networks were investigated. Finally, in vitro cytotoxicity screening of polymer networks based on ISO10993-5 revealed high cell viability (over 77%) regardless of curing atmosphere. Overall, our results indicate that this heterometallic magnesium-titanium butoxide catalyst can be an attractive alternative to commonly used homometallic catalysts for the synthesis of injectable and photocurable materials for medical applications. The Royal Society of Chemistry 2023-06-19 /pmc/articles/PMC10277904/ /pubmed/37342811 http://dx.doi.org/10.1039/d3ra02157b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Niedźwiedź, Malwina J.
Ignaczak, Wojciech
Sobolewski, Peter
Goszczyńska, Agata
Demirci, Gokhan
El Fray, Miroslawa
Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks
title Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks
title_full Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks
title_fullStr Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks
title_full_unstemmed Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks
title_short Injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks
title_sort injectable and photocurable macromonomers synthesized using a heterometallic magnesium–titanium metal–organic catalyst for elastomeric polymer networks
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277904/
https://www.ncbi.nlm.nih.gov/pubmed/37342811
http://dx.doi.org/10.1039/d3ra02157b
work_keys_str_mv AT niedzwiedzmalwinaj injectableandphotocurablemacromonomerssynthesizedusingaheterometallicmagnesiumtitaniummetalorganiccatalystforelastomericpolymernetworks
AT ignaczakwojciech injectableandphotocurablemacromonomerssynthesizedusingaheterometallicmagnesiumtitaniummetalorganiccatalystforelastomericpolymernetworks
AT sobolewskipeter injectableandphotocurablemacromonomerssynthesizedusingaheterometallicmagnesiumtitaniummetalorganiccatalystforelastomericpolymernetworks
AT goszczynskaagata injectableandphotocurablemacromonomerssynthesizedusingaheterometallicmagnesiumtitaniummetalorganiccatalystforelastomericpolymernetworks
AT demircigokhan injectableandphotocurablemacromonomerssynthesizedusingaheterometallicmagnesiumtitaniummetalorganiccatalystforelastomericpolymernetworks
AT elfraymiroslawa injectableandphotocurablemacromonomerssynthesizedusingaheterometallicmagnesiumtitaniummetalorganiccatalystforelastomericpolymernetworks