Novel and Engineered Type II CRISPR Systems from Uncultivated Microbes with Broad Genome Editing Capability

Type II Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 nucleases have been extensively used in biotechnology and therapeutics. However, many applications are not possible owing to the size, targetability, and potential off-target effects associated with currently known syste...

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Detalles Bibliográficos
Autores principales: Alexander, Lisa M., Aliaga Goltsman, Daniela S., Liu, Jason, Lin, Jyun-Liang, Temoche-Diaz, Morayma M., Laperriere, Sarah M., Neerincx, Andreas, Bednarski, Christien, Knyphausen, Philipp, Cohnen, Andre, Albers, Justine, Gonzalez-Osorio, Liliana, Fregoso Ocampo, Rodrigo, Oki, Jennifer, Devoto, Audra E., Castelle, Cindy J., Lamothe, Rebecca C., Cost, Gregory J., Butterfield, Cristina N., Thomas, Brian C., Brown, Christopher T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278012/
https://www.ncbi.nlm.nih.gov/pubmed/37272861
http://dx.doi.org/10.1089/crispr.2022.0090

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