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The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Bacillus anthracis and Brucella melitensis
INTRODUCTION: Brucella melitensis and Bacillus anthracis are zoonoses transmitted from animals and animal products. Scientific information is provided in this article to support biosafety precautions necessary to protect laboratory workers and individuals who are potentially exposed to these pathoge...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Mary Ann Liebert, Inc., publishers
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278026/ https://www.ncbi.nlm.nih.gov/pubmed/37342513 http://dx.doi.org/10.1089/apb.2022.0042 |
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author | Blacksell, Stuart D. Dhawan, Sandhya Kusumoto, Marina Le, Kim Khanh Summermatter, Kathrin O'Keefe, Joseph Kozlovac, Joseph Almuhairi, Salama Suhail Sendow, Indrawati Scheel, Christina M. Ahumibe, Anthony Masuku, Zibusiso M. Bennett, Allan M. Kojima, Kazunobu Harper, David R. Hamilton, Keith |
author_facet | Blacksell, Stuart D. Dhawan, Sandhya Kusumoto, Marina Le, Kim Khanh Summermatter, Kathrin O'Keefe, Joseph Kozlovac, Joseph Almuhairi, Salama Suhail Sendow, Indrawati Scheel, Christina M. Ahumibe, Anthony Masuku, Zibusiso M. Bennett, Allan M. Kojima, Kazunobu Harper, David R. Hamilton, Keith |
author_sort | Blacksell, Stuart D. |
collection | PubMed |
description | INTRODUCTION: Brucella melitensis and Bacillus anthracis are zoonoses transmitted from animals and animal products. Scientific information is provided in this article to support biosafety precautions necessary to protect laboratory workers and individuals who are potentially exposed to these pathogens in the workplace or other settings, and gaps in information are also reported. There is a lack of information on the appropriate effective concentration for many chemical disinfectants for this agent. Controversies related to B. anthracis include infectious dose for skin and gastrointestinal infections, proper use of personal protective equipment (PPE) during the slaughter of infected animals, and handling of contaminated materials. B. melitensis is reported to have the highest number of laboratory-acquired infections (LAIs) to date in laboratory workers. METHODS: A literature search was conducted to identify potential gaps in biosafety and focused on five main sections including the route of inoculation/modes of transmission, infectious dose, LAIs, containment releases, and disinfection and decontamination strategies. RESULTS: Scientific literature currently lacks information on the effective concentration of many chemical disinfectants for this agent and in the variety of matrices where it may be found. Controversies related to B. anthracis include infectious dose for skin and gastrointestinal infections, proper use of PPE during the slaughter of infected animals, and handling contaminated materials. DISCUSSION: Clarified vulnerabilities based on specific scientific evidence will contribute to the prevention of unwanted and unpredictable infections, improving the biosafety processes and procedures for laboratory staff and other professionals such as veterinarians, individuals associated with the agricultural industry, and those working with susceptible wildlife species. |
format | Online Article Text |
id | pubmed-10278026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Mary Ann Liebert, Inc., publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-102780262023-06-20 The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Bacillus anthracis and Brucella melitensis Blacksell, Stuart D. Dhawan, Sandhya Kusumoto, Marina Le, Kim Khanh Summermatter, Kathrin O'Keefe, Joseph Kozlovac, Joseph Almuhairi, Salama Suhail Sendow, Indrawati Scheel, Christina M. Ahumibe, Anthony Masuku, Zibusiso M. Bennett, Allan M. Kojima, Kazunobu Harper, David R. Hamilton, Keith Appl Biosaf Review Articles INTRODUCTION: Brucella melitensis and Bacillus anthracis are zoonoses transmitted from animals and animal products. Scientific information is provided in this article to support biosafety precautions necessary to protect laboratory workers and individuals who are potentially exposed to these pathogens in the workplace or other settings, and gaps in information are also reported. There is a lack of information on the appropriate effective concentration for many chemical disinfectants for this agent. Controversies related to B. anthracis include infectious dose for skin and gastrointestinal infections, proper use of personal protective equipment (PPE) during the slaughter of infected animals, and handling of contaminated materials. B. melitensis is reported to have the highest number of laboratory-acquired infections (LAIs) to date in laboratory workers. METHODS: A literature search was conducted to identify potential gaps in biosafety and focused on five main sections including the route of inoculation/modes of transmission, infectious dose, LAIs, containment releases, and disinfection and decontamination strategies. RESULTS: Scientific literature currently lacks information on the effective concentration of many chemical disinfectants for this agent and in the variety of matrices where it may be found. Controversies related to B. anthracis include infectious dose for skin and gastrointestinal infections, proper use of PPE during the slaughter of infected animals, and handling contaminated materials. DISCUSSION: Clarified vulnerabilities based on specific scientific evidence will contribute to the prevention of unwanted and unpredictable infections, improving the biosafety processes and procedures for laboratory staff and other professionals such as veterinarians, individuals associated with the agricultural industry, and those working with susceptible wildlife species. Mary Ann Liebert, Inc., publishers 2023-06-01 2023-06-05 /pmc/articles/PMC10278026/ /pubmed/37342513 http://dx.doi.org/10.1089/apb.2022.0042 Text en © Stuart D. Blacksell et al. 2023; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by/4.0/This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Blacksell, Stuart D. Dhawan, Sandhya Kusumoto, Marina Le, Kim Khanh Summermatter, Kathrin O'Keefe, Joseph Kozlovac, Joseph Almuhairi, Salama Suhail Sendow, Indrawati Scheel, Christina M. Ahumibe, Anthony Masuku, Zibusiso M. Bennett, Allan M. Kojima, Kazunobu Harper, David R. Hamilton, Keith The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Bacillus anthracis and Brucella melitensis |
title | The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Bacillus anthracis and Brucella melitensis |
title_full | The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Bacillus anthracis and Brucella melitensis |
title_fullStr | The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Bacillus anthracis and Brucella melitensis |
title_full_unstemmed | The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Bacillus anthracis and Brucella melitensis |
title_short | The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Bacillus anthracis and Brucella melitensis |
title_sort | biosafety research road map: the search for evidence to support practices in the laboratory—bacillus anthracis and brucella melitensis |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278026/ https://www.ncbi.nlm.nih.gov/pubmed/37342513 http://dx.doi.org/10.1089/apb.2022.0042 |
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