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Steady-State Pharmacokinetics of Intravenous Hydromorphone in Japanese Patients With Renal Impairment and Cancer Pain

BACKGROUND: The opioid analgesic hydromorphone has a low renal excretion ratio; however, exposure after oral administration is several times higher in those with moderate or severe renal impairment. OBJECTIVES: We evaluated the impact of renal impairment on the steady-state pharmacokinetics of intra...

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Detalles Bibliográficos
Autores principales:	Nakatani, Toshihiko, Shiosakai, Kazuhito, Hashimoto, Tatsuya, Shionoya, Masao, Akasaka, Takaaki, Toyama, Kaoru, Ishizuka, Hitoshi, Saito, Yoji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278029/ https://www.ncbi.nlm.nih.gov/pubmed/36579915 http://dx.doi.org/10.1089/jpm.2022.0289

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