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Cardiometabolic disease risk factors in pre- and postmenopausal women from four sub-Saharan African countries: A cross-sectional study

OBJECTIVE: To compare the risk factors for cardiometabolic disease between pre- and postmenopausal women from four sub-Saharan African countries. STUDY DESIGN: This cross-sectional study included 3609 women (1740 premenopausal and 1869 postmenopausal) from sites in Ghana (Navrongo), Burkina Faso (Na...

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Autores principales: Chikwati, Raylton P., Mahyoodeen, Nasrin Goolam, Jaff, Nicole G., Ramsay, Michele, Micklesfield, Lisa K., Wade, Alisha N., Agongo, Godfred, Asiki, Gershim, Choma, Solomon S.R., Boua, Palwende R., George, Jaya A., Crowther, Nigel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278059/
https://www.ncbi.nlm.nih.gov/pubmed/37116348
http://dx.doi.org/10.1016/j.maturitas.2023.04.005
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author Chikwati, Raylton P.
Mahyoodeen, Nasrin Goolam
Jaff, Nicole G.
Ramsay, Michele
Micklesfield, Lisa K.
Wade, Alisha N.
Agongo, Godfred
Asiki, Gershim
Choma, Solomon S.R.
Boua, Palwende R.
George, Jaya A.
Crowther, Nigel J.
author_facet Chikwati, Raylton P.
Mahyoodeen, Nasrin Goolam
Jaff, Nicole G.
Ramsay, Michele
Micklesfield, Lisa K.
Wade, Alisha N.
Agongo, Godfred
Asiki, Gershim
Choma, Solomon S.R.
Boua, Palwende R.
George, Jaya A.
Crowther, Nigel J.
author_sort Chikwati, Raylton P.
collection PubMed
description OBJECTIVE: To compare the risk factors for cardiometabolic disease between pre- and postmenopausal women from four sub-Saharan African countries. STUDY DESIGN: This cross-sectional study included 3609 women (1740 premenopausal and 1869 postmenopausal) from sites in Ghana (Navrongo), Burkina Faso (Nanoro), Kenya (Nairobi), and South Africa (Soweto and Dikgale). Demographic, anthropometric and cardiometabolic variables were compared between pre- and postmenopausal women, within and across sites using multivariable regression analyses. The sites represent populations at different stages of the health transition, with those in Ghana and Burkina Faso being rural, whilst those in Kenya and South Africa are more urbanised. MAIN OUTCOME MEASURES: Anthropometric and cardiometabolic variables. RESULTS: The prevalence rates of risk factors for cardiometabolic disease were higher in South (Soweto and Dikgale) and East (Nairobi) Africa than in West Africa (Nanoro and Navrongo), irrespective of menopausal status. Regression models in combined West African populations demonstrated that postmenopausal women had a larger waist circumference (β = 1.28 (95 % CI: 0.58; 1.98) cm), log subcutaneous fat (β =0.15 (0.10; 0.19)) diastolic (β = 3.04 (1.47; 4.62) mm Hg) and log systolic (β = 0.04 (0.02; 0.06)) blood pressure, log carotid intima media thickness (β = 0.03 (0.01; 0.06)), low-density lipoprotein cholesterol (β = 0.14 (0.04; 0.23) mmol/L) and log triglyceride (β= 0.10 (0.04; 0.16)) levels than premenopausal women. No such differences were observed in the South and East African women. CONCLUSIONS: Menopause-related differences in risk factors for cardiometabolic disease were prominent in West but not East or South African study sites. These novel findings should inform cardiometabolic disease prevention strategies in midlife women specific to rural and urban and peri-urban locations in sub-Saharan Africa.
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spelling pubmed-102780592023-06-19 Cardiometabolic disease risk factors in pre- and postmenopausal women from four sub-Saharan African countries: A cross-sectional study Chikwati, Raylton P. Mahyoodeen, Nasrin Goolam Jaff, Nicole G. Ramsay, Michele Micklesfield, Lisa K. Wade, Alisha N. Agongo, Godfred Asiki, Gershim Choma, Solomon S.R. Boua, Palwende R. George, Jaya A. Crowther, Nigel J. Maturitas Article OBJECTIVE: To compare the risk factors for cardiometabolic disease between pre- and postmenopausal women from four sub-Saharan African countries. STUDY DESIGN: This cross-sectional study included 3609 women (1740 premenopausal and 1869 postmenopausal) from sites in Ghana (Navrongo), Burkina Faso (Nanoro), Kenya (Nairobi), and South Africa (Soweto and Dikgale). Demographic, anthropometric and cardiometabolic variables were compared between pre- and postmenopausal women, within and across sites using multivariable regression analyses. The sites represent populations at different stages of the health transition, with those in Ghana and Burkina Faso being rural, whilst those in Kenya and South Africa are more urbanised. MAIN OUTCOME MEASURES: Anthropometric and cardiometabolic variables. RESULTS: The prevalence rates of risk factors for cardiometabolic disease were higher in South (Soweto and Dikgale) and East (Nairobi) Africa than in West Africa (Nanoro and Navrongo), irrespective of menopausal status. Regression models in combined West African populations demonstrated that postmenopausal women had a larger waist circumference (β = 1.28 (95 % CI: 0.58; 1.98) cm), log subcutaneous fat (β =0.15 (0.10; 0.19)) diastolic (β = 3.04 (1.47; 4.62) mm Hg) and log systolic (β = 0.04 (0.02; 0.06)) blood pressure, log carotid intima media thickness (β = 0.03 (0.01; 0.06)), low-density lipoprotein cholesterol (β = 0.14 (0.04; 0.23) mmol/L) and log triglyceride (β= 0.10 (0.04; 0.16)) levels than premenopausal women. No such differences were observed in the South and East African women. CONCLUSIONS: Menopause-related differences in risk factors for cardiometabolic disease were prominent in West but not East or South African study sites. These novel findings should inform cardiometabolic disease prevention strategies in midlife women specific to rural and urban and peri-urban locations in sub-Saharan Africa. 2023-06 2023-04-20 /pmc/articles/PMC10278059/ /pubmed/37116348 http://dx.doi.org/10.1016/j.maturitas.2023.04.005 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Chikwati, Raylton P.
Mahyoodeen, Nasrin Goolam
Jaff, Nicole G.
Ramsay, Michele
Micklesfield, Lisa K.
Wade, Alisha N.
Agongo, Godfred
Asiki, Gershim
Choma, Solomon S.R.
Boua, Palwende R.
George, Jaya A.
Crowther, Nigel J.
Cardiometabolic disease risk factors in pre- and postmenopausal women from four sub-Saharan African countries: A cross-sectional study
title Cardiometabolic disease risk factors in pre- and postmenopausal women from four sub-Saharan African countries: A cross-sectional study
title_full Cardiometabolic disease risk factors in pre- and postmenopausal women from four sub-Saharan African countries: A cross-sectional study
title_fullStr Cardiometabolic disease risk factors in pre- and postmenopausal women from four sub-Saharan African countries: A cross-sectional study
title_full_unstemmed Cardiometabolic disease risk factors in pre- and postmenopausal women from four sub-Saharan African countries: A cross-sectional study
title_short Cardiometabolic disease risk factors in pre- and postmenopausal women from four sub-Saharan African countries: A cross-sectional study
title_sort cardiometabolic disease risk factors in pre- and postmenopausal women from four sub-saharan african countries: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278059/
https://www.ncbi.nlm.nih.gov/pubmed/37116348
http://dx.doi.org/10.1016/j.maturitas.2023.04.005
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